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Laser diode based nanosecond pulsed light sources for optoacoustic microscopy
Optoacoustic microscopy combines optical contrast with penetration depth of ultrasound allowing functional and structural imaging in highly scattering biological tissues. Cost and bulkiness of conventional lasers decrease applicability in clinics which could be avoided by using pulsable LEDs.
The existing multi-wavelength acoustic resolution optoacoustic microscope is based on three independent lasers (Nd:YAG, frequency doubled Nd:YAG, and Dye laser) which are combined in a single optical path and coupled into a multimode fiber delivering the light to the tissue to excite absorbers which consequently emit ultrasound waves. Large field-of-views can be scanned in a mechanical overfly scan in several minutes acquiring volumetric images of vasculature in the human skin.
Applicability of optoacoustic microscopy in clinical settings in partially hindered by the high cost and volume of conventional light sources. To make the system more compact and less expensive, we want to evaluate the usability of pulsable LEDs for illumination at multiple wavelengths.
Basic knowledge in optics is required. The student should have profound experience in developing electrical circuits for the driver electronics. Experience with lab setups and data collection is of advantage.
The existing multi-wavelength acoustic resolution optoacoustic microscope is based on three independent lasers (Nd:YAG, frequency doubled Nd:YAG, and Dye laser) which are combined in a single optical path and coupled into a multimode fiber delivering the light to the tissue to excite absorbers which consequently emit ultrasound waves. Large field-of-views can be scanned in a mechanical overfly scan in several minutes acquiring volumetric images of vasculature in the human skin.
Applicability of optoacoustic microscopy in clinical settings in partially hindered by the high cost and volume of conventional light sources. To make the system more compact and less expensive, we want to evaluate the usability of pulsable LEDs for illumination at multiple wavelengths.
Basic knowledge in optics is required. The student should have profound experience in developing electrical circuits for the driver electronics. Experience with lab setups and data collection is of advantage.
Based on existing research, the student should evaluate the usability of different pulsable LEDs for acoustic resolution optoacoustic microscopy starting with a proof-of-principle using a single wavelength. The light source needs to provide sufficient per-pulse-energy at kilohertz rates and nanosecond pulse lengths. Afterwards, multiple wavelengths emitted by different LEDs should be combined into a single optical fiber.
Based on existing research, the student should evaluate the usability of different pulsable LEDs for acoustic resolution optoacoustic microscopy starting with a proof-of-principle using a single wavelength. The light source needs to provide sufficient per-pulse-energy at kilohertz rates and nanosecond pulse lengths. Afterwards, multiple wavelengths emitted by different LEDs should be combined into a single optical fiber.
Please send a brief introduction and your CV to Urs Hofmann (hofmannu@ethz.ch) and Prof. Daniel Razansky (danir@ethz.ch).
Functional and Molecular Imaging, Department of Information Technology and Electrical Engineering, ETH Zurich
razanskylab.org
Please send a brief introduction and your CV to Urs Hofmann (hofmannu@ethz.ch) and Prof. Daniel Razansky (danir@ethz.ch).
Functional and Molecular Imaging, Department of Information Technology and Electrical Engineering, ETH Zurich