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Mechanoregulation of diabetic bone remodelling using HRpQCT in vivo patient data
Diabetes mellitus is a widespread metabolic disease, which disrupts the entire organism of patients. This also significantly affects bone health. The consequences are an increased risk of fractures and a worse healing of bone fractures.
Keywords: Bone, Mechanobiology, Diabetes, HRpQCT imaging, image processing, finite element analysis, Deep Learning, Computer Vision, Software Development
Within the FIDELIO.eu project we work on pushing bone imaging and computational methods for mechanobiological bone remodeling studies from bench (supercomputer) to the bedside (clinical computing) in the hospital environment. These approaches will then be used to investigate the effects of diabetes mellitus (DM) on local mechanoregulation of bone remodeling in T1DM and T2DM as well as appropriate controls, identifying its relationship to bone fragility, and biomarkers, which are directly linked to this impairment in mechanoregulation.
Within the FIDELIO.eu project we work on pushing bone imaging and computational methods for mechanobiological bone remodeling studies from bench (supercomputer) to the bedside (clinical computing) in the hospital environment. These approaches will then be used to investigate the effects of diabetes mellitus (DM) on local mechanoregulation of bone remodeling in T1DM and T2DM as well as appropriate controls, identifying its relationship to bone fragility, and biomarkers, which are directly linked to this impairment in mechanoregulation.
Depending on the project (Semester-, Bachelor-, Master- Thesis) the specific tasks and goals will differ and will be defined after a personal meeting with the student depending on their interest. We welcome students from any background with interest in Bone, Mechanobiology, Diabetes, HRpQCT Imaging, Image processing, Finite Element Analysis, Deep Learning and Computer Vision, or Software Development.
4 general areas of projects are available:
**AI Computer Vision & Deep Learning**:
- Image2Image translation: Deep learning: Super-resolution HR-pQCT imaging to investigate mechanoregulation in patients
- Classification: VGS Classification of HR-pQCT: Automatic grading score for HR-pQCT images
**Agent-based multiphysics modelling of bone (AMP):**
- Digital Biopsies: Optimization of in silico multiphysics models in bone.
- Simulating bone pathophysiology in patients with T2DM using the AMP
**Advection Based Remodeling: Bone on Tissue level**
- Comparison of advection based remodeling using different measurements of mechanical strain.
**Mechanoregulation - Basic Research**
- Effects of Image Quality on the Quantification of subject-specific load estimation for Patients
- Super-sampling of finite element analysis - From Bench to Bedside
- Morphological analysis of remodeling regions- Identify artifacts from HR-pQCT imaging
- Local mechanoregulation analysis of individual trabeculae
**Meta-Analysis**
- Advanced Glycation End products and Bone Material Properties in DM
Depending on the project (Semester-, Bachelor-, Master- Thesis) the specific tasks and goals will differ and will be defined after a personal meeting with the student depending on their interest. We welcome students from any background with interest in Bone, Mechanobiology, Diabetes, HRpQCT Imaging, Image processing, Finite Element Analysis, Deep Learning and Computer Vision, or Software Development.
4 general areas of projects are available:
**AI Computer Vision & Deep Learning**: - Image2Image translation: Deep learning: Super-resolution HR-pQCT imaging to investigate mechanoregulation in patients - Classification: VGS Classification of HR-pQCT: Automatic grading score for HR-pQCT images
**Agent-based multiphysics modelling of bone (AMP):** - Digital Biopsies: Optimization of in silico multiphysics models in bone. - Simulating bone pathophysiology in patients with T2DM using the AMP
**Advection Based Remodeling: Bone on Tissue level** - Comparison of advection based remodeling using different measurements of mechanical strain.
**Mechanoregulation - Basic Research** - Effects of Image Quality on the Quantification of subject-specific load estimation for Patients - Super-sampling of finite element analysis - From Bench to Bedside - Morphological analysis of remodeling regions- Identify artifacts from HR-pQCT imaging - Local mechanoregulation analysis of individual trabeculae
**Meta-Analysis** - Advanced Glycation End products and Bone Material Properties in DM
Due to corona, we may also host remote projects (based on pre-existing clinical, or rodent in-vivo data) which do not require physical presence but a stable internet connection.
Please do not hesitate to contact me with an informal e-mail (matthias.walle@hest.ethz.ch) so we can work out a project tailored to your interests!
International students are welcome to apply!
Currently there are only unpaid positions available.
Due to corona, we may also host remote projects (based on pre-existing clinical, or rodent in-vivo data) which do not require physical presence but a stable internet connection.
Please do not hesitate to contact me with an informal e-mail (matthias.walle@hest.ethz.ch) so we can work out a project tailored to your interests!
International students are welcome to apply!
Currently there are only unpaid positions available.