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Master project on viscoelastic properties of aging C. elegans
Glycation and Advanced glycation end products are major complication of diabetic patients and the elderly population. Here, we aim to establish a new in-vivo and fast-aging model to assess these consequences using the model organism C. elegans
We are looking for a master student with engineering and/or biophysics background. Candidate must be in the ETH Masters program. No experience with C. elegans or molecular biology or genetics required.
We are looking for a master student with engineering and/or biophysics background. Candidate must be in the ETH Masters program. No experience with C. elegans or molecular biology or genetics required.
The overall goal is to re-built the "bending device" described in this paper doi: 10.1073/pnas.1219965110 with the remote help of the authors of this paper. Then test bending stiffness of aging C. elegans and identify mechanisms to prevent stiffening of collagens. These mechanisms might be conserved in mammals helping to identify novel strategies against age-dependent glycation or collagen crosslinking as seen in diabetes patients.
The overall goal is to re-built the "bending device" described in this paper doi: 10.1073/pnas.1219965110 with the remote help of the authors of this paper. Then test bending stiffness of aging C. elegans and identify mechanisms to prevent stiffening of collagens. These mechanisms might be conserved in mammals helping to identify novel strategies against age-dependent glycation or collagen crosslinking as seen in diabetes patients.
Please, send CV, a paragraph explaining your motivation working on this project and highlighting your skills for engineering and/or biophysics to rebuild this machine and analyse resulting data. Please, email at collin-ewald(at)ethz.ch
For more info please visit: www.ewaldlab.com
Please, send CV, a paragraph explaining your motivation working on this project and highlighting your skills for engineering and/or biophysics to rebuild this machine and analyse resulting data. Please, email at collin-ewald(at)ethz.ch For more info please visit: www.ewaldlab.com