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3D printed multimodal drug delivery system
In this project, we will use additive manufacturing to fabricate advanced drug delivery systems.
The freedom of design provided by AM combined with an in-house developed biomaterial platform[1] will be exploited to control the spatial distribution of the drugs and to design specific release profile.
In vitro studies will be performed to characterize the efficiency of the produced drug delivery systems.
Keywords: Engineering, 3D printing, biomaterials, drug delivery system, polymer
Additive manufacturing is a rapidly evolving field, with a lot of potential for medical applications. In the pharmaceutical sector, 3D printing provides the ability to design new formulations for improved drug delivery. Moreover, this technology will facilitate the production of systems containing multiple active ingredients (polypills or multimodal drugs).
In this project, we aim to design advanced drug delivery systems that have different drug release profiles and enable the temporal control of released drugs. Initially, mechanical and chemical characterization will be performed on fabricated constructs. The second part of this project will focus on the in vitro characterization to test toxicity and efficiency of the fabricated system.
For this master thesis project (or semester project) we are looking for an enterprising student with background in pharmaceutical science, chemistry, chemical engineering, biomedical engineering, material science or similar field. Previous experience in drug formulation, biology or material design is beneficial but not required. Some tasks of the project can be tailored to the interests of the student.
References:
[1]: Guzzi et al., _Small_ (2019)
Additive manufacturing is a rapidly evolving field, with a lot of potential for medical applications. In the pharmaceutical sector, 3D printing provides the ability to design new formulations for improved drug delivery. Moreover, this technology will facilitate the production of systems containing multiple active ingredients (polypills or multimodal drugs). In this project, we aim to design advanced drug delivery systems that have different drug release profiles and enable the temporal control of released drugs. Initially, mechanical and chemical characterization will be performed on fabricated constructs. The second part of this project will focus on the in vitro characterization to test toxicity and efficiency of the fabricated system.
For this master thesis project (or semester project) we are looking for an enterprising student with background in pharmaceutical science, chemistry, chemical engineering, biomedical engineering, material science or similar field. Previous experience in drug formulation, biology or material design is beneficial but not required. Some tasks of the project can be tailored to the interests of the student.
References: [1]: Guzzi et al., _Small_ (2019)
The master thesis project will focus on the development of a new approach to temporally control the release profile of drugs.
Techniques and skills:
- 3D printing and CAD 3D model design
- Biomaterial characterization
- Drug release
– Bio-lab / Cell-culture
The master thesis project will focus on the development of a new approach to temporally control the release profile of drugs. Techniques and skills: - 3D printing and CAD 3D model design - Biomaterial characterization - Drug release – Bio-lab / Cell-culture
Elia Guzzi (guzzie@ethz.ch)
Prof. Mark Tibbitt (mtibbitt@ethz.ch)
Elia Guzzi (guzzie@ethz.ch) Prof. Mark Tibbitt (mtibbitt@ethz.ch)