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Pharmacological upregulation of prostate-specific membrane antigen (PSMA) expression for improved prostate cancer imaging and therapy.
Prostate-specific membrane antigen (PSMA)-based imaging and therapy are increasingly used for prostate cancer management. However, limitations are a low PSMA surface expression in certain tumors. Androgen receptor axis inhibition can induce PSMA expression in vitro.
Keywords: prostate cancer, PSMA
We are testing different approved compounds and compound combinations on their ability to upregulate PSMA expression in vitro and in vivo.
We are testing different approved compounds and compound combinations on their ability to upregulate PSMA expression in vitro and in vivo.
Not specified
Dr. med. Benedikt Kranzbühler, benedikt.kranzbuehler@usz.ch
Dr. med. Benedikt Kranzbühler, benedikt.kranzbuehler@usz.ch