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Multiplex fluorescence imaging of human tissue
In situ interrogation of dozens of molecules including proteins and RNAs by multiplex imaging in their native 3D tissue volume depicts the original spatial localization of complex tissue components and holds extensive applications in biomedical research. Here we would develop a simple and robust multiplex 3D imaging method based on new readout and tissue clearing to achieve highly multiplex 3D molecular mapping of human biopsy. Single cell spatial relationship and cell-cell interactions in 3D niche would be analysed using advanced computational methods.
Keywords: Fluorescence imaging, single cell analysis, human tissue
The project includes hand-on practices in wet-lab to handle antibody, DNA, human tissue etc. with well-designed experiments, and computational analysis with R, python.
The project includes hand-on practices in wet-lab to handle antibody, DNA, human tissue etc. with well-designed experiments, and computational analysis with R, python.
If you manage to generate beautiful fluorescence images and develop new algorithm/package for single cell analysis, there would be a publication:).
If you manage to generate beautiful fluorescence images and develop new algorithm/package for single cell analysis, there would be a publication:).
Shan Zhao, Dr.
shan.zhao@uzh.ch
University of Zurich, Campus Irchel
Department of Quantitative Biomedicine
Winterthurerstrasse 190, Y38M
8057 Zurich
Switzerland
Shan Zhao, Dr. shan.zhao@uzh.ch University of Zurich, Campus Irchel Department of Quantitative Biomedicine Winterthurerstrasse 190, Y38M 8057 Zurich Switzerland