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Data-driven Modelling of Cerebrospinal Fluid Dynamics for Hardware-in-the-Loop Shunt Testing
Development and testing of intelligent mechatronic shunt systems for hydrocephalus requires a sophisticated model of cerebrospinal fluid dynamics. In this work, you will conduct data-driven biomedical system modelling on real physiologic data and hardware-in-the-loop testing of shunt systems.
Keywords: Modelling and Identification
Embedded Control Systems
Hardware-in-the-Loop
This project is part of a collaboration between the IDSC and the pd|z. We aim to develop a SmartShunt, an intelligent mechatronic shunt system for the therapy of hydrocephalus. Hydrocephalus is a medical condition characterized by the excessive accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles and is treated by shunts diverting the CSF through a pressure valve out of the enlarged ventricles. The technology hasn’t changed notably during the last 60 years, still leading to high failure rates and insufficient therapy because these passive and differential pressure driven shunts are incapable of properly analyzing and controlling CSF dynamics.
This project is part of a collaboration between the IDSC and the pd|z. We aim to develop a SmartShunt, an intelligent mechatronic shunt system for the therapy of hydrocephalus. Hydrocephalus is a medical condition characterized by the excessive accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles and is treated by shunts diverting the CSF through a pressure valve out of the enlarged ventricles. The technology hasn’t changed notably during the last 60 years, still leading to high failure rates and insufficient therapy because these passive and differential pressure driven shunts are incapable of properly analyzing and controlling CSF dynamics.
Your task will be to support the development of a test set-up for the next generation of shunt systems. Firstly, you will design a sophisticated model of CSF dynamics using an extensive in-vivo data set and deploy it onto an already existing hardware-in-the-loop test bench which is depicted in the figure on the bottom right. Secondly, you will design and implement physio- and pathological test sequences which you will use to conduct hardware-in-the-loop test to investigate the performance of shunt systems.
Your task will be to support the development of a test set-up for the next generation of shunt systems. Firstly, you will design a sophisticated model of CSF dynamics using an extensive in-vivo data set and deploy it onto an already existing hardware-in-the-loop test bench which is depicted in the figure on the bottom right. Secondly, you will design and implement physio- and pathological test sequences which you will use to conduct hardware-in-the-loop test to investigate the performance of shunt systems.
Knowledge and experience in system modelling methodology (applied to biomedical systems a plus)
Ability to draw from different experiential sources and apply to a single task
An analytical mind and curiosity into the different applications that system modelling has in the biomedical space
The chair of Product Development and Engineering Design at the ETH Zurich considers itself a center for system-oriented product development and innovation. Our aspiration consists on the one hand of the advancement and investigation of methods and processes of product development and on the other hand of the development of new technical systems. The purpose of our daily work is to contribute to the innovative ability and competitiveness of Switzerland.
The chair of Product Development and Engineering Design at the ETH Zurich considers itself a center for system-oriented product development and innovation. Our aspiration consists on the one hand of the advancement and investigation of methods and processes of product development and on the other hand of the development of new technical systems. The purpose of our daily work is to contribute to the innovative ability and competitiveness of Switzerland.
Collaboration between PDZ, IDSC, and USZ
Interdisciplinary project in biomedical/electrical engineering
Learn how a large, inter-institutional project operates effectively and efficiently
Anthony Podgorsak, pdz
apodgorsak@ethz.ch
Fabian Flürenbrock, IDSC
ffluerenb@ethz.ch
Anthony Podgorsak, pdz apodgorsak@ethz.ch Fabian Flürenbrock, IDSC ffluerenb@ethz.ch