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Magnetoelctric Nanocomposite Microrobots for Neuron Cell Delivery and Differentiation
In this project, we would like to develop a nanocomposite helical microrobots based on piezoelectric materials, which can be employed to deliver neuron cells, and, at the same time, to promote the cell differentiation through wireless electrostimulation.
Neurotrauma and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, result in irreversible structural disruption of the neuronal network accompanied by cell death. Unfortunately, adults have limited capability to actively regenerate or replace neuron cells.
Our previous work has demonstrated that using ultrasound stimulation, piezoelectric materials can induce differentiation of neuron-like cells even in absence of neuron growth factors.
In this project, we would like to develop a nanocomposite helical microrobots based on piezoelectric materials, which can be employed to deliver neuron cells, and, at the same time, to promote the cell differentiation through wireless electrostimulation.
The student will develop microrobots, optimize the fabrication parameters, study the swimming behavior of microrobots, characterize the materials properties, investigate the influence of the materials properties on cell behaviors.
Whom we want:
A Highly motivated and Active Master Student. Cell culturing and imaging experiences will be a big plus but not necessary. The student is expected to start as soon as possible.
What you will get:
* Knowledge and Experiences on microrobot fabrication, various materials characterization techniques, cell culturing and imaging techniques.
* Hopefully a peer-reviewed journal paper.
Neurotrauma and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, result in irreversible structural disruption of the neuronal network accompanied by cell death. Unfortunately, adults have limited capability to actively regenerate or replace neuron cells. Our previous work has demonstrated that using ultrasound stimulation, piezoelectric materials can induce differentiation of neuron-like cells even in absence of neuron growth factors. In this project, we would like to develop a nanocomposite helical microrobots based on piezoelectric materials, which can be employed to deliver neuron cells, and, at the same time, to promote the cell differentiation through wireless electrostimulation. The student will develop microrobots, optimize the fabrication parameters, study the swimming behavior of microrobots, characterize the materials properties, investigate the influence of the materials properties on cell behaviors.
Whom we want: A Highly motivated and Active Master Student. Cell culturing and imaging experiences will be a big plus but not necessary. The student is expected to start as soon as possible.
What you will get: * Knowledge and Experiences on microrobot fabrication, various materials characterization techniques, cell culturing and imaging techniques. * Hopefully a peer-reviewed journal paper.
To demonstrate the proof of concept of a microrobots for neuron cell delivery and differentiation using magnetoelectric/piezoelectric stimulation.
To demonstrate the proof of concept of a microrobots for neuron cell delivery and differentiation using magnetoelectric/piezoelectric stimulation.