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Nutraceutical-based treatment of inflammatory bowel disease
Inflammatory Bowel disease (IBD) affects ~5 million people worldwide. We aim to develop of a targeted functional food would help improve the daily lives of those suffering from IBD.
Keywords: Nutraceutical, anti-inflammatory, immunoengineering, functional food, bowel, therapeutic, gut
Over 2.5 million Europeans are estimated to have inflammatory bowel disease (IBD). This disease is extremely debilitating and those who suffer from IBD may have difficulties to perform simple tasks on a day-to-day basis. The two most prominent types of IBD are Crohn’s disease and ulcerative colitis the most common symptoms of which include severe abdominal pain and chronic diarrhea. Current therapeutics include anti-inflammatory compounds and immunosuppressors most of which have off target systemic effects. Therefore, the development of a functional food which directly targets the intestinal and/or colonic mucosa could be very beneficial to the treatment and wellbeing of patients with IBD.
This project is ideal for a semester project or internship.
Over 2.5 million Europeans are estimated to have inflammatory bowel disease (IBD). This disease is extremely debilitating and those who suffer from IBD may have difficulties to perform simple tasks on a day-to-day basis. The two most prominent types of IBD are Crohn’s disease and ulcerative colitis the most common symptoms of which include severe abdominal pain and chronic diarrhea. Current therapeutics include anti-inflammatory compounds and immunosuppressors most of which have off target systemic effects. Therefore, the development of a functional food which directly targets the intestinal and/or colonic mucosa could be very beneficial to the treatment and wellbeing of patients with IBD.
This project is ideal for a semester project or internship.
The overall goal of this project is to identify and characterize the ability for specific nutraceuticals to attenuate inflammation of intestinal and colonic tissue and ultimately to develop a “functional food” that can be administered to patients which suffer from inflammatory bowel disease.
The overall goal of this project is to identify and characterize the ability for specific nutraceuticals to attenuate inflammation of intestinal and colonic tissue and ultimately to develop a “functional food” that can be administered to patients which suffer from inflammatory bowel disease.
Matthew Randall, mrandall@ethz.ch / Institute for Biomechanics, HPP-O13, ETH Zürich / Professorship Karin Würtz-Kozak
Matthew Randall, mrandall@ethz.ch / Institute for Biomechanics, HPP-O13, ETH Zürich / Professorship Karin Würtz-Kozak