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Metabolomics and Flux Balance Analysis in Saccharomyces cerevisiae
Research project available on investigating the regulation of metabolism in S. cerevisiae, via enzyme phosphorylation
Keywords: Systems biology
Metabolism
Mass Spectrometry
Flux balance analysis
Physiology
Phosphorylation
In order to function optimally in diverse environments, cells need to regulate their metabolic fluxes in response to changes in nutrient availability. We are combining detailed physiological measurements with mathematical models of metabolism to generate hypotheses about the regulation of metabolism via enzyme phosphorylation.
This project represents an opportunity for you to perform a systems biology research project that involves growing yeast cultures, measuring samples with high-throughput enzyme assays and state-of-the-art metabolomics technology, and analyzing data using genome-scale flux balance analysis.
This project will involve approximately 70% wet-lab and 30% computational work. Proficiency with MATLAB/python is beneficial but not required.
In order to function optimally in diverse environments, cells need to regulate their metabolic fluxes in response to changes in nutrient availability. We are combining detailed physiological measurements with mathematical models of metabolism to generate hypotheses about the regulation of metabolism via enzyme phosphorylation.
This project represents an opportunity for you to perform a systems biology research project that involves growing yeast cultures, measuring samples with high-throughput enzyme assays and state-of-the-art metabolomics technology, and analyzing data using genome-scale flux balance analysis.
This project will involve approximately 70% wet-lab and 30% computational work. Proficiency with MATLAB/python is beneficial but not required.
Not specified
If you are interested, please contact Brendan Ryback (ryback@imsb.biol.ethz.ch) or Zrinka Raguz Nakic (raguz@imsb.biol.ethz.ch)
If you are interested, please contact Brendan Ryback (ryback@imsb.biol.ethz.ch) or Zrinka Raguz Nakic (raguz@imsb.biol.ethz.ch)