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Development of a numerical model to investigate cerebrospinal fluid dynamics
Hydrocephalus is a disease characterized by an excess accumulation of cerebrospinal fluid (CSF). Using previously acquired acute and chronic pressure data from preclinical trials, a novel numerical model linking CSF, blood, and possibly abdominal pressure is to be investigated.
Keywords: System Modeling
System Modelling
Signal Processing
System Identification
Numerical Modeling
Numerical Modelling
MATLAB
Simulink
Control Theory
Control
Mechanical Engineering
Electrical Engineering
Hydrocephalus
Hydrocephalus is a disease characterized by an excess accumulation of cerebrospinal fluid (CSF). This accumulated CSF can lead to a slew of clinical sequelae, including impaired gait, memory loss, incontinence, etc. Little is understood about the precursors to Hydrocephalus - but a detailed understanding of CSF dynamics and interactions with surrounding physiologic compartments is required before a treatment evolution can be designed. We have conducted acute and chronic sheep trials with the simultaneous measurement of the CSF, blood, and abdominal systems.
This Thesis aims to marry the cranio-spinal, blood, and abdominal compartments in a single numerical model that accurately reflects the interconnected nature of these regions. Working in collaboration with the University Hospital Zurich, this is a multi-institutional project with real life impact.
Hydrocephalus is a disease characterized by an excess accumulation of cerebrospinal fluid (CSF). This accumulated CSF can lead to a slew of clinical sequelae, including impaired gait, memory loss, incontinence, etc. Little is understood about the precursors to Hydrocephalus - but a detailed understanding of CSF dynamics and interactions with surrounding physiologic compartments is required before a treatment evolution can be designed. We have conducted acute and chronic sheep trials with the simultaneous measurement of the CSF, blood, and abdominal systems.
This Thesis aims to marry the cranio-spinal, blood, and abdominal compartments in a single numerical model that accurately reflects the interconnected nature of these regions. Working in collaboration with the University Hospital Zurich, this is a multi-institutional project with real life impact.
First off, you will become acquainted with current physiologic models from literature, where they are strong, where they are weak, etc. From this, you will then become acquainted with our acquired physiologic data and see the potential for the effective modeling of this data.
Based off this, you will design and validate a numerical model in MATLAB Simulink based on data from our acute and chronic trials that accurately reflects the observed phenomena.
Once you compare the efficacy of the derived model to those already existing in literature, we would like for this model to be tested on our state-of-the-art testbench linking the abdominal and cranio-spinal compartments.
First off, you will become acquainted with current physiologic models from literature, where they are strong, where they are weak, etc. From this, you will then become acquainted with our acquired physiologic data and see the potential for the effective modeling of this data.
Based off this, you will design and validate a numerical model in MATLAB Simulink based on data from our acute and chronic trials that accurately reflects the observed phenomena.
Once you compare the efficacy of the derived model to those already existing in literature, we would like for this model to be tested on our state-of-the-art testbench linking the abdominal and cranio-spinal compartments.
1. Previous experience in numerical system modeling and signal processing methodology
2. Strong in MATLAB with experience using Simulink
3. Motivated to work on a truly state-of-the-art project with wide-reaching impact
4. Eager to work on a large, interdisciplinary, and inter-institutional project
You will learn:
1. How computational tools are truly shaping the world of contemporary medicine
2. How to translate research data into discoveries with legitimate impact to benefit the lives of patients
3. How a large, multi-institutional project with many stakeholders operates efficiently in a strongly regulated environment
The Biomedical Systems group at the pdz focused on biomedical problems that affect our world and how we can better address them using the state-of-the-art. From Hydrocephalus to Low Cost Ventilators, we aim to improve treatment options for those inflicted with problems yet to be solved. With strong collaborations in industry and academia, we are at the forefront of biomedical-related research across the world
The Biomedical Systems group at the pdz focused on biomedical problems that affect our world and how we can better address them using the state-of-the-art. From Hydrocephalus to Low Cost Ventilators, we aim to improve treatment options for those inflicted with problems yet to be solved. With strong collaborations in industry and academia, we are at the forefront of biomedical-related research across the world
1. You will gain hands-on experience in applications of system modeling at the forefront of the state-of-the-art 2. You will be actively integrated into our project team comprised of engineers, scientists, and cliniciana