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Hypoxia-related stress responses in skin and aging
The skin is an important barrier against environmental insults but susceptable to hypoxia-mediated degradation during aging. We will investigate the mechanisms by which hypoxia produces an aging phenotype.
Keywords: aging, oxidative stress, extracellular matrix, hypoxia, protein modification, skin
The skin is the primary barrier against environmental insults from UV irradiation to toxins (pollution), and pathogens. Therefore, maintaining a healthy skin is important for survival and longevity. A consequence of aging is the loss of structural integrity of the skin such as the degradation of elastin and collagen and poor cellular function. Aging of the skin is recognized by the presence of wrinkles, and a general dryer/thinner appearance. Aging is associated with a general decrease in oxygen supply, hypoxia. Hypoxia results in the abundance of reactive oxygen species that disrupt cellular homeostasis. Hypoxia-mediated degradation of keratins, collagens or elastins is not well described. Therefore, it is important to investigate the impact of hypoxia on aging and integrity of the skin as a barrier against environmental challenges.
The skin is the primary barrier against environmental insults from UV irradiation to toxins (pollution), and pathogens. Therefore, maintaining a healthy skin is important for survival and longevity. A consequence of aging is the loss of structural integrity of the skin such as the degradation of elastin and collagen and poor cellular function. Aging of the skin is recognized by the presence of wrinkles, and a general dryer/thinner appearance. Aging is associated with a general decrease in oxygen supply, hypoxia. Hypoxia results in the abundance of reactive oxygen species that disrupt cellular homeostasis. Hypoxia-mediated degradation of keratins, collagens or elastins is not well described. Therefore, it is important to investigate the impact of hypoxia on aging and integrity of the skin as a barrier against environmental challenges.
The overall goal of this project is to measure keratinocyte responses to hypoxia in relation to the expression of proteins critical for loss of skin integrity found in aging.
The overall goal of this project is to measure keratinocyte responses to hypoxia in relation to the expression of proteins critical for loss of skin integrity found in aging.
Matthew Randall, mrandall@ethz.ch / Institute for Biomechanics, HPP-O13, ETH Zürich / Professorship Karin Würtz-Kozak
Matthew Randall, mrandall@ethz.ch / Institute for Biomechanics, HPP-O13, ETH Zürich / Professorship Karin Würtz-Kozak