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High-Throughput Microfluidic Tools for C. elegans Screens (deMello Group)
The ability to process large cohorts of C. elegans is a current hurdle for biologists working with this powerful model organism. We aim to implement microfluidic solutions to empower experimentation with the worm.
Keywords: Microfluidics, C. elegans, deMello Group
C. elegans is one of the most powerful model organisms used in many areas of Biology. Advantages of working with C. elegans involve short lifespans, well known genome and simple genetic manipulation and maintenance protocols. On the other hand, due to their small size - 1.2 mm length - lack of "gentle" manipulation techniques (reagentless, stress-free) for large amounts of organisms (required for "omics" assays) represents a bottleneck. We are developing microfluidic tools for the high-throughput screening of C. elegans, in particular for age-synchronization, immobilization, sorting (larval stages, dead vs. alive) and homeostatic maintenance in liquid media.
http://www.youtube.com/watch?feature=player_embedded&v=WwRgTBeCVSk
C. elegans is one of the most powerful model organisms used in many areas of Biology. Advantages of working with C. elegans involve short lifespans, well known genome and simple genetic manipulation and maintenance protocols. On the other hand, due to their small size - 1.2 mm length - lack of "gentle" manipulation techniques (reagentless, stress-free) for large amounts of organisms (required for "omics" assays) represents a bottleneck. We are developing microfluidic tools for the high-throughput screening of C. elegans, in particular for age-synchronization, immobilization, sorting (larval stages, dead vs. alive) and homeostatic maintenance in liquid media.
Design microfluidic chips capable of processing large populations of C. elegans nematodes for different purposes (e.g. sort according to larval stage), in a simple and inexpensive manner.
Design microfluidic chips capable of processing large populations of C. elegans nematodes for different purposes (e.g. sort according to larval stage), in a simple and inexpensive manner.
Dr. Xavier Casadevall i Solvas
Senior Scientist. ICB - Department of Chemistry and Applied Biosciences
ETH Zürich CH-8093 Zurich Switzerland
e-mail: xavier.casadevall@chem.ethz.ch
Phone: +41 (0) 44 633 04 20
Fax: +41 (0)44 633 1252
Dr. Xavier Casadevall i Solvas
Senior Scientist. ICB - Department of Chemistry and Applied Biosciences