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Development of a portable MEMS-enabled fluorescence tomography system
Fluorescence molecular tomography (FMT) provides molecular information on tracer bio-distribution in the organism similar to positron emission tomography (PET). Instead of using radioactive tracers in PET, FMT non-invasively resolves the three-dimensional distribution of fluorescent probes in vivo. Thus, it can be considered an optical version of PET (but only 1% cost of PET). A miniaturized FMT with compact design and easy handling is certainly attractive. This calls for the integration of MEMS and customized components facilitated with 3D printer technology. Previously we have developed a compact FMT standalone system and an FMT/MRI hybrid system, which serves as a starting point for the project.
Keywords: Optical imaging, 3D printing, MEMS
The project is under the framework of ‘KaleiBox’ project, a BRIDGE Proof-of-concept project (2018-2020). ‘KaleiBox’ won Venturekick prize in 2019 and was presented in Swiss Pavilion in Hannover Messe 2019.
**Media:**
http://bridge.ch/en/proof-of-concept/supported-projects-2017/
https://www.startupticker.ch/en/news/april-2019/strong-swiss-presence-at-the-hannover-messe
**Requirement:**
Students with backgrounds of applied optics, electrical engineering, mechanical engineering or biomedical engineering are highly encouraged to apply.
**What we offer:**
1. Solid and hands-on training in medical imaging field: from simulation to prototype
2. Excellent workshop facility with high freedom to practice
3. Great teamwork atmosphere
**Reference:**
1. Darne C, Lu Y, Sevick-Muraca EM (2013) Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update. Phys Med Biol
2. Ren W, Elmer A, Buehlmann D, et al. (2015) Dynamic Measurement of Tumor Vascular Permeability and Perfusion using a Hybrid System for Simultaneous Magnetic Resonance and Fluorescence Imaging. Mol Imaging Biol
3. Ren, W., H. Isler, M. Wolf, J. Ripoll, and M. Rudin. (2019) Smart Toolkit for Fluorescence Tomography: simulation, reconstruction, and validation, IEEE Trans Biomed Eng.
The project is under the framework of ‘KaleiBox’ project, a BRIDGE Proof-of-concept project (2018-2020). ‘KaleiBox’ won Venturekick prize in 2019 and was presented in Swiss Pavilion in Hannover Messe 2019.
Students with backgrounds of applied optics, electrical engineering, mechanical engineering or biomedical engineering are highly encouraged to apply.
**What we offer:**
1. Solid and hands-on training in medical imaging field: from simulation to prototype
2. Excellent workshop facility with high freedom to practice
3. Great teamwork atmosphere
**Reference:**
1. Darne C, Lu Y, Sevick-Muraca EM (2013) Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update. Phys Med Biol
2. Ren W, Elmer A, Buehlmann D, et al. (2015) Dynamic Measurement of Tumor Vascular Permeability and Perfusion using a Hybrid System for Simultaneous Magnetic Resonance and Fluorescence Imaging. Mol Imaging Biol
3. Ren, W., H. Isler, M. Wolf, J. Ripoll, and M. Rudin. (2019) Smart Toolkit for Fluorescence Tomography: simulation, reconstruction, and validation, IEEE Trans Biomed Eng.
- System design with a focus on optical design
- Customized components using 3D printing
- Control graphic user interface (GUI) development
- Performance evaluation with silicone phantom
- System design with a focus on optical design
- Customized components using 3D printing
- Control graphic user interface (GUI) development
- Performance evaluation with silicone phantom
Dr. Wuwei Ren
Email: ren@biomed.ee.ethz.ch
Phone: +41 44 633 76 52
Prof. Martin Wolf
Email: Martin.Wolf@usz.ch
Phone: +41 44 255 53 46