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Postdoctoral position in translational rheumatology research
The group of Prof. Ospelt at the Center of Experimental Rheumatology is seeking an experienced post-doctoral researcher for its interdisciplinary research team (100%).
Keywords: Post-doc, fibroblasts, translational research
The Center of Experimental Rheumatology Zurich belongs to the world leading institutes in the study of stromal changes in chronic inflammatory joint diseases and analyses epigenetic, transcriptional and functional changes of synovial fibroblasts in patient’s samples.
The current project comprises the analysis of the spatial distribution and function of distinct synovial fibroblast subtypes identified in synovial tissues. We built an extensive genomic, epigenomic, transcriptomic and single cell RNA-seq data set that we want to complement with spatial transcriptomics data. Furthermore, functional co-culture experiments with synovial fibroblasts and other relevant cell types (monocytes/macrophages, endothelial cell, lymphocytes) will be developed in 3D culture systems.
The Center of Experimental Rheumatology Zurich belongs to the world leading institutes in the study of stromal changes in chronic inflammatory joint diseases and analyses epigenetic, transcriptional and functional changes of synovial fibroblasts in patient’s samples. The current project comprises the analysis of the spatial distribution and function of distinct synovial fibroblast subtypes identified in synovial tissues. We built an extensive genomic, epigenomic, transcriptomic and single cell RNA-seq data set that we want to complement with spatial transcriptomics data. Furthermore, functional co-culture experiments with synovial fibroblasts and other relevant cell types (monocytes/macrophages, endothelial cell, lymphocytes) will be developed in 3D culture systems.
**Your profile**
We are looking for a highly-motivated post-doctoral researcher with strong expertise in molecular-biology methods as well as in bioinformatics analyses.
Specific qualifications include:
- Experience in cell culture and standard molecular biology techniques (FACS, Western blotting, qPCR, ELISA, etc.)
- Expertise in the analysis of –omics data sets and programming skills with R
- Ability to work independently, high problem-solving skills and strong motivation to learn and establish new methods and protocols
- High interpersonal, intercultural and social competence with cross-disciplinary aptitude
- Ability to keep a detailed research log and summarize work in research reports, presentations, abstracts and manuscripts
- Fluent in oral and written English
**What we offer**
- Work in an internationally known research lab with an interdisciplinary team
- Personal development opportunity and independent working conditions
- Supportive and favorable working environment
- High quality of location, competitive salary and healthy work/life balance
**Your profile** We are looking for a highly-motivated post-doctoral researcher with strong expertise in molecular-biology methods as well as in bioinformatics analyses. Specific qualifications include:
- Experience in cell culture and standard molecular biology techniques (FACS, Western blotting, qPCR, ELISA, etc.)
- Expertise in the analysis of –omics data sets and programming skills with R
- Ability to work independently, high problem-solving skills and strong motivation to learn and establish new methods and protocols
- High interpersonal, intercultural and social competence with cross-disciplinary aptitude
- Ability to keep a detailed research log and summarize work in research reports, presentations, abstracts and manuscripts
- Fluent in oral and written English
**What we offer** - Work in an internationally known research lab with an interdisciplinary team
- Personal development opportunity and independent working conditions
- Supportive and favorable working environment
- High quality of location, competitive salary and healthy work/life balance
If you are interested, please send your CV with a motivation letter to caroline.ospelt@usz.ch
If you are interested, please send your CV with a motivation letter to caroline.ospelt@usz.ch