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Internship in Biomaterials in Davos up to 12 months
We are looking for a motivated and enthusiastic individual to join our research team at the AO Research Institute Davos (ARI), actively contributing to a project that explores the interactions between biomaterials and immune cells. The expected duration of the internship is 12 months. We offer assistance in finding accommodation.
Keywords: Biomaterials, immunomodulation, 3D printing, surface topography.
Tissue regeneration and homeostasis after injury or biomaterial implantation are controlled by a spectrum of components of the immune system and their mutual regulation. The initial immune response at the site of inflammation is led by neutrophils, which are the first responders to be recruited and as such orchestrate the progression of the subsequent inflammatory events after implantation.
Tissue regeneration and homeostasis after injury or biomaterial implantation are controlled by a spectrum of components of the immune system and their mutual regulation. The initial immune response at the site of inflammation is led by neutrophils, which are the first responders to be recruited and as such orchestrate the progression of the subsequent inflammatory events after implantation.
In this project, we will study the **effect of different surface topographies on behavior of neutrophils and peripheral blood monocytes derived macrophages**, and to find out the how sequential exposure of neutrophils and macrophages influences the differentiation of mesenchymal stromal cells (MSCs) and healing response. With this investigation we will create an in vitro platform to better understand how different players of the immune system contribute to interacting with biomaterials and, to test the role of immune signaling on MSC differentiation. Gaining a deeper understanding in the complex interplay between the innate immune cells and MSCs will allow us to develop platforms for** assessing the immunomodulatory properties of the materials**.
In this project, we will study the **effect of different surface topographies on behavior of neutrophils and peripheral blood monocytes derived macrophages**, and to find out the how sequential exposure of neutrophils and macrophages influences the differentiation of mesenchymal stromal cells (MSCs) and healing response. With this investigation we will create an in vitro platform to better understand how different players of the immune system contribute to interacting with biomaterials and, to test the role of immune signaling on MSC differentiation. Gaining a deeper understanding in the complex interplay between the innate immune cells and MSCs will allow us to develop platforms for** assessing the immunomodulatory properties of the materials**.
• Prof. Matteo D'Este (PhD),
Head of Biomedical Materials, AO Research Institute, Davos
E-mail: matteo.deste@aofoundation.org
• Ezgi Irem Bektas (PhD),
Postdoctoral Researcher, Biomedical Materials AO Research Institute Davos
E-mail: ezgi.bektas@aofoundation.org
• Prof. Matteo D'Este (PhD), Head of Biomedical Materials, AO Research Institute, Davos E-mail: matteo.deste@aofoundation.org
• Ezgi Irem Bektas (PhD), Postdoctoral Researcher, Biomedical Materials AO Research Institute Davos E-mail: ezgi.bektas@aofoundation.org
