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Electrospun polymer nanofibers for tissue engineering and regenerative medicine.
Micromechanical and biological characterization of electro spun polycaprolactone nanofibers for tissue engineering scaffolds and regenerative medicine.
The project is placed in the scope of a larger study on inter-vertebral disc regeneration. The method proposed requires tuning mechanical biocompatibility of electrospun polycaprolactone scaffolds to withstand cyclic loading experienced by the tissue in vivo, while maintaining biocompatibility and appropriate cell adhesion and viability. To develop an appropriate scaffold a deeper understanding of micromechanical properties is necessary.
This project is focused on investigating the mechanical and biological properties of electrospun polycaprolactone single nano-fibers (100nm-4um) in relation to varying production techniques and conditions. You will have an opportunity to work on advanced electrospinning equipment for fiber production. Learn and use a wide variety of material characterization techniques such as 3D laser scanning microscopy, SEM, diffraction microscopy and others, and finally use a nano-mechanical testing robot arm (FemtoTool) to investigate the mechanics of the fibers. The results will then be compared to the native tissue, and the structure refined to better match biomechanical properties.
The work will be done across several groups in the Biomechanics institute within D-HEST and D-MATL.
The project is placed in the scope of a larger study on inter-vertebral disc regeneration. The method proposed requires tuning mechanical biocompatibility of electrospun polycaprolactone scaffolds to withstand cyclic loading experienced by the tissue in vivo, while maintaining biocompatibility and appropriate cell adhesion and viability. To develop an appropriate scaffold a deeper understanding of micromechanical properties is necessary. This project is focused on investigating the mechanical and biological properties of electrospun polycaprolactone single nano-fibers (100nm-4um) in relation to varying production techniques and conditions. You will have an opportunity to work on advanced electrospinning equipment for fiber production. Learn and use a wide variety of material characterization techniques such as 3D laser scanning microscopy, SEM, diffraction microscopy and others, and finally use a nano-mechanical testing robot arm (FemtoTool) to investigate the mechanics of the fibers. The results will then be compared to the native tissue, and the structure refined to better match biomechanical properties. The work will be done across several groups in the Biomechanics institute within D-HEST and D-MATL.
Establish consequential relationship from production process to material properties and their effect on mechanical properties and biocompatibility of electrospun polycaprolactone single nano-fibers.
Establish consequential relationship from production process to material properties and their effect on mechanical properties and biocompatibility of electrospun polycaprolactone single nano-fibers.