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PhD Position on Stimulated Raman Scattering Microscopy
The group of Experimental Imaging and Neuroenergetics (Prof. Bruno Weber) at the University of Zurich is seeking a PhD student for a new project on Stimulated Raman Scattering (SRS) microscopy. The lab has longstanding experience in in-vivo (mainly two-photon) imaging technologies (calcium, FRET, FLIM, SHG/THG) combined to stimulation protocols in anesthetized and awake mice. As part of our investigations, we are interested in the distribution and consumption of glucose in different cell types in the brain. The implementation of SRS, combined with specially designed glucose derivatives, is a very powerful tool to address such questions in a minimally invasive way, while at the same time producing advanced structural information. The project will focus on the implementation of the technique in one of our custom-built multi-photon microscopes, involving precise optical alignment and fast beam modulation, detector design, advanced lock-in amplification-based detection strategies and data analysis (including deep-learning based denoising strategies). The ideal candidate should have a background in engineering or physics, with strong interest in the application of measurement hardware and advanced data analysis for the implementation of new technologies in life science experiments. We offer a cutting-edge experimental infrastructure and a dedicated supervision in a multidisciplinary team at Irchel Campus of UZH.