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PhD student position: Molecular and functional identification of basolateral phosphate transporter(s)
Phosphate is an essential mineral that must be absorbed from diet, is redistributed between different organs, and is either excreted into urine or reabsorbed by kidneys. These processes require a set of dedicated phosphate transporters. While several classes of phosphate transporters are known that mediate the apical uptake of phosphate into epithelial cells, the molecular identity of the transporters needed to release phosphate basolaterally has remained elusive.
Keywords: Molecular and cell biology, transporter, phosphate, intestine, kidney
The project is located at the Institute of Physiology (group C.A. Wagner). The PhD is embedded into the PhD program “Biomedicine” under the umbrella of the Life Science Graduate School Zurich.
We are seeking a highly motivated, team-oriented graduate candidate with a strong interest
in molecular and cell biology associated with an understanding of complex metabolic and endocrine functions, who is eager to work in a modern laboratory environment and to apply cutting-edge genomic, cell biology and bioinformatics technologies.
The successful candidate should hold a diploma or a master’s degree in the field of Molecular Biology, Biomedical Sciences or a related subject together with good bioinformatic knowledge. Proficiency in English, knowledge and bioinformatics and data analysis as well as a good knowledge of cell biology are required.
We offer a highly stimulating and diverse research environment with state-of-the art infrastructure. The salary of the position is according to the regulations of the Swiss National Science Foundation.
The project is located at the Institute of Physiology (group C.A. Wagner). The PhD is embedded into the PhD program “Biomedicine” under the umbrella of the Life Science Graduate School Zurich.
We are seeking a highly motivated, team-oriented graduate candidate with a strong interest in molecular and cell biology associated with an understanding of complex metabolic and endocrine functions, who is eager to work in a modern laboratory environment and to apply cutting-edge genomic, cell biology and bioinformatics technologies.
The successful candidate should hold a diploma or a master’s degree in the field of Molecular Biology, Biomedical Sciences or a related subject together with good bioinformatic knowledge. Proficiency in English, knowledge and bioinformatics and data analysis as well as a good knowledge of cell biology are required.
We offer a highly stimulating and diverse research environment with state-of-the art infrastructure. The salary of the position is according to the regulations of the Swiss National Science Foundation.
The aims of the PhD project are 1) to identify candidate molecules for basolateral phosphate transporters using a combination of bioinformatic tools, omics technologies, and CRISPR/Cas, 2) to validate candidates in cellular models and localize their expression in tissues using intestinal/renal samples, cell culture and functional assays, 3) and to finally validate candidates in vivo by developing transgenic animal models.
The aims of the PhD project are 1) to identify candidate molecules for basolateral phosphate transporters using a combination of bioinformatic tools, omics technologies, and CRISPR/Cas, 2) to validate candidates in cellular models and localize their expression in tissues using intestinal/renal samples, cell culture and functional assays, 3) and to finally validate candidates in vivo by developing transgenic animal models.
Please direct your inquiries to C.A.Wagner, wagnerca@access.uzh.ch, including your CV, letters of reference or contact addresses of references, as well as transcripts of courses and degrees as a single pdf file.
Please direct your inquiries to C.A.Wagner, wagnerca@access.uzh.ch, including your CV, letters of reference or contact addresses of references, as well as transcripts of courses and degrees as a single pdf file.