Interactions between biomolecules are fundamental in all biological processes and regulatory networks. NMR spectroscopy is among the key methods to study such interactions, but until recently it had little exposure in Systems Biology applications. We are developing new methods at intersection of NMR and Computational Systems Biology - allowing to rapidly gain insight into complex interacting systems. Computation-interested student(s) are sought to help developing these further.
One direction involves a balanced mixture of wet-lab, NMR spectroscopy and computational work – to study the effects of proteins on folding of various disease-related RNAs.
Second direction has stronger focus on computational analysis (clustering algorithms in particular) – to speed up discovery in Protein-RNA interactions and network perturbations.
The projects are suitable for students with:
- wet-lab experience, and interest to learn NMR and deepen computational skills
or
- computational experience, and interest to learn NMR and wet-lab work
Basic Matlab experience is beneficial, but not a requirement.
Interactions between biomolecules are fundamental in all biological processes and regulatory networks. NMR spectroscopy is among the key methods to study such interactions, but until recently it had little exposure in Systems Biology applications. We are developing new methods at intersection of NMR and Computational Systems Biology - allowing to rapidly gain insight into complex interacting systems. Computation-interested student(s) are sought to help developing these further.
One direction involves a balanced mixture of wet-lab, NMR spectroscopy and computational work – to study the effects of proteins on folding of various disease-related RNAs.
Second direction has stronger focus on computational analysis (clustering algorithms in particular) – to speed up discovery in Protein-RNA interactions and network perturbations.
The projects are suitable for students with:
- wet-lab experience, and interest to learn NMR and deepen computational skills
or
- computational experience, and interest to learn NMR and wet-lab work
Basic Matlab experience is beneficial, but not a requirement.
Not specified
Applications including a CV and a brief statement of motivation should be sent to Dr. Yaroslav Nikolaev (yaroslav.nikolaev@mol.biol.ethz.ch) and/or Prof. Frederic Allain (allain@mol.biol.ethz.ch)
Applications including a CV and a brief statement of motivation should be sent to Dr. Yaroslav Nikolaev (yaroslav.nikolaev@mol.biol.ethz.ch) and/or Prof. Frederic Allain (allain@mol.biol.ethz.ch)