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Design of safe and controlled deployment of novel polymeric heart valve during transcatheter implanation
The main goal of this project is to develop a deployment system that allows safe and controlled deployment of the novel polymeric heart valve in the transcatheter heart valve replacement procedure.
The polymeric heart valve (PHV) is a promising alternative for the transcatheter heart valve replacement (THVR). It could potentially provide multiple advantages over the bioprosthetic
heart valve (BPHV), such as higher durability,
lower manufacturing cost, simpler storage requirement, etc.
CMASLab has been developing a novel PHV which consists of carbon fibre reinforced polymer (CFRP) laminate and polymeric leaflets. One of the current challenges is the incompatibility of the conventional deployment system of BPHV to the novel PHV. The deployment of the BPHV in a THVR procedure is accomplished by unsheathing. This method is not compatible to the novel PHV due to the abrupt release of the elastic energy stored in the CFRP stent. This leads to an uncontrolled and rapid deployment of the novel PHV, which is unacceptable from patient safety point of view. On that account, a novel concept for the deployment
system has been devised.
The polymeric heart valve (PHV) is a promising alternative for the transcatheter heart valve replacement (THVR). It could potentially provide multiple advantages over the bioprosthetic heart valve (BPHV), such as higher durability, lower manufacturing cost, simpler storage requirement, etc. CMASLab has been developing a novel PHV which consists of carbon fibre reinforced polymer (CFRP) laminate and polymeric leaflets. One of the current challenges is the incompatibility of the conventional deployment system of BPHV to the novel PHV. The deployment of the BPHV in a THVR procedure is accomplished by unsheathing. This method is not compatible to the novel PHV due to the abrupt release of the elastic energy stored in the CFRP stent. This leads to an uncontrolled and rapid deployment of the novel PHV, which is unacceptable from patient safety point of view. On that account, a novel concept for the deployment system has been devised.
The main objective of this semester project is to assess the potential of a new design for safe and controlled delivery. The design process will involve the consideration of spatial constraint set by the diameter of the transcatheter delivery device and external stresses applied to the deployment system during the THVR procedure. In the final stage of the project, the deployment system will be manufactured and tested in a bench-top heart surrogate model.
The main objective of this semester project is to assess the potential of a new design for safe and controlled delivery. The design process will involve the consideration of spatial constraint set by the diameter of the transcatheter delivery device and external stresses applied to the deployment system during the THVR procedure. In the final stage of the project, the deployment system will be manufactured and tested in a bench-top heart surrogate model.
Jacopo Cossu, E-mail: cossuj@ethz.ch, Please send your CV and a transcript of records
Jacopo Cossu, E-mail: cossuj@ethz.ch, Please send your CV and a transcript of records