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Screening Microenvironmental Cues for In Vitro Human Bone Models
3D in vitro models provide a valuable way to study human biology without using animals. However, these models are primarily based on poorly defined animal-derived hydrogels, such as Matrigel or collagen. This limits our detailed understanding of cell-material interactions in bone development, maintenance, and repair. Importantly, these mechanisms are often disrupted in various bone diseases, highlighting the needs for more advanced in vitro models.
Keywords: biomaterials, hydrogels, in vitro models, tissue engineering
Building on state-of-the-arts in bone tissue engineering, this project aims to characterize and optimize 3D cell culture conditions for human bone in vitro models. The project aims to employ advanced hydrogel matrices for 3D osteogenic culture and investigate key molecular and cellular biomarkers over time, opening up new avenues for understanding bone biology in health and disease in the laboratory.
Building on state-of-the-arts in bone tissue engineering, this project aims to characterize and optimize 3D cell culture conditions for human bone in vitro models. The project aims to employ advanced hydrogel matrices for 3D osteogenic culture and investigate key molecular and cellular biomarkers over time, opening up new avenues for understanding bone biology in health and disease in the laboratory.
The primary objective of this project is to screen optimal 3D cell culture conditions (i.e., biochemical and biophysical cues) for an in vitro human bone model. This will involve the screening of the effects of different soluble and insoluble cues on osteogenic differentiation during 3D cell culture. Based on these findings, we aim to mimic 3D tissue environments in vitro to advance our understandings of human bone biology.
The primary objective of this project is to screen optimal 3D cell culture conditions (i.e., biochemical and biophysical cues) for an in vitro human bone model. This will involve the screening of the effects of different soluble and insoluble cues on osteogenic differentiation during 3D cell culture. Based on these findings, we aim to mimic 3D tissue environments in vitro to advance our understandings of human bone biology.
Marion Horrer, PhD candidate (marion.horrer@hest.ethz.ch), and Dr. Xiao-Hua Qin (qinx@ethz.ch), Senior Scientist & Team Lead, Institute for Biomechanics, ETH Zürich
For application, please provide your CV, Transcripts of B.Sc. and M.Sc., contacts of 2 references.
Marion Horrer, PhD candidate (marion.horrer@hest.ethz.ch), and Dr. Xiao-Hua Qin (qinx@ethz.ch), Senior Scientist & Team Lead, Institute for Biomechanics, ETH Zürich
For application, please provide your CV, Transcripts of B.Sc. and M.Sc., contacts of 2 references.
