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Development of Novel Lateral Flow Assay Compatible with Electrochemical Readout
You will optimize a lateral flow assay (LFA) to make it compatible with our novel highly sensitive electrochemical readout that will form a cornerstone for the ground-breaking point-of-need diagnostics device. You will be working on assay development with a focus, amongst others, on decreasing the non-specific binding of analyte and detection nanoparticles to the LFA membrane matrix, increasing sensitivity by optimizing the chemical environment of the immune-sandwich formation, nanoparticle/receptor conjugation or capillary flow optimization.
You will work on an interdisciplinary project in collaboration with ETH spin-off Hemetron (https://www.hemetron.com/, https://www.linkedin.com/company/hemetron/). This fast pace project is ideal for highly motivated students.
o We predict that ten years from now, most of the visits to the physician's office will be done via video call instead of an in-person appointment. The main obstacle to such a telemedical revolution is an absence of blood testing of patients directly at their homes, and can be solved by our newly developed biosensor. Our system is based on electrochemical (EC) detection of gold nanoparticles from conventional LFA rapid antigen tests.
o As a proof of concept, we have developed an LFA test with EC readout for SARS-CoV-2 antigen, which is going to be validated in a clinical trial. We are currently developing tests for inflammation biomarkers that will be used for patient triage at home.
o At this moment, we are further optimizing the optimal lateral flow assay conditions for electrochemical readout to unlock our new biosensor's full potential.
o We offer the opportunity to work on a project with an immediate impact on patient health in a highly interdisciplinary environment and in close collaboration with a startup company.
o If you are a skilled student passionate about acquiring various interdisciplinary skills, please contact me by email with your CV attached.
o We predict that ten years from now, most of the visits to the physician's office will be done via video call instead of an in-person appointment. The main obstacle to such a telemedical revolution is an absence of blood testing of patients directly at their homes, and can be solved by our newly developed biosensor. Our system is based on electrochemical (EC) detection of gold nanoparticles from conventional LFA rapid antigen tests. o As a proof of concept, we have developed an LFA test with EC readout for SARS-CoV-2 antigen, which is going to be validated in a clinical trial. We are currently developing tests for inflammation biomarkers that will be used for patient triage at home. o At this moment, we are further optimizing the optimal lateral flow assay conditions for electrochemical readout to unlock our new biosensor's full potential. o We offer the opportunity to work on a project with an immediate impact on patient health in a highly interdisciplinary environment and in close collaboration with a startup company. o If you are a skilled student passionate about acquiring various interdisciplinary skills, please contact me by email with your CV attached.
o Optimize LFA to unlock the full potential of highly sensitive electrochemical readout
o Develop a new LFA assay to increase the possibility of the home testing device
o Optimize LFA for a better user interface
o Optimize LFA to unlock the full potential of highly sensitive electrochemical readout o Develop a new LFA assay to increase the possibility of the home testing device o Optimize LFA for a better user interface
