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Investigating degeneration of bone cells in a mouse model of senile osteoporosis
Age-related bone loss and associated fractures result in osteoporosis, a major problem for the elderly. Several studies suggested as a therapeutic target to prevent bone loss by precise coordination of bone remodeling through the interaction of bone cells namely: osteoclast-bone resorbing cells, osteoblasts-bone forming cells and osteocytes-key mechanosensors of bone remodeling. To understand the cellular mechanism of aging, this project investigates the degenerative changes in the bone cells in a mouse model of senile osteoporosis.
Keywords: aging, in vivo mouse models, bone cells, osteoclasts, osteoblasts, osteocytes, osteoporosis, in vitro cell culture, confocal imaging
Age-related bone loss and consequent osteoporosis due to the imbalance in bone remodeling are mainly related to the alterations of the bone cells. To better understand the underlying reason for osteoporosis, changes in the bone cells’ morphology and identification of molecular targets need to be investigated.
Age-related bone loss and consequent osteoporosis due to the imbalance in bone remodeling are mainly related to the alterations of the bone cells. To better understand the underlying reason for osteoporosis, changes in the bone cells’ morphology and identification of molecular targets need to be investigated.
With the above in mind, the goal of this project is to study age-related degeneration of bone cells in a mouse model of senile osteoporosis. The student will be introduced to combination of methods: cell culture, histology, immunostainings, gene expression techniques, high-resolution imaging with a 3D confocal microscopy. The student will receive interdisciplinary training with hands-on experience in the field of bone biomechanics. This project is fit for Biology, Biochemistry, Biomedical Engineering and Interdisciplinary Science students, but any well-qualified candidate may apply.
With the above in mind, the goal of this project is to study age-related degeneration of bone cells in a mouse model of senile osteoporosis. The student will be introduced to combination of methods: cell culture, histology, immunostainings, gene expression techniques, high-resolution imaging with a 3D confocal microscopy. The student will receive interdisciplinary training with hands-on experience in the field of bone biomechanics. This project is fit for Biology, Biochemistry, Biomedical Engineering and Interdisciplinary Science students, but any well-qualified candidate may apply.
Dilara Yilmaz, dilara.yilmaz@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller
Dilara Yilmaz, dilara.yilmaz@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller