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Engineering therapeutic genetic circuits in mammalian cells
Cell-based therapies have emerged as a powerful platform for treating pathological phenotypes [1]. A focus of synthetic biology is to engineer cellular systems that can act by releasing therapeutic effectors to mitigate disease states [2]. Developing such circuits remains a great challenge. The goal of this project is to engineer genetic circuits in human cells and establish cell lines for therapeutic applications. Within this task, the prospective student may explore different genetic topologies and develop various cell line engineering workflows and co-culture assays.
Keywords: Mammalian synthetic biology, synthetic gene circuits, control systems
References:
1. Caleb J Bashor et al. “Engineering the next generation of cell-based therapeutics”. In: Nature Reviews Drug Discovery 21.9 (2022), pp. 655–675.
2. Wendell A Lim. “The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function”. In: Science 378.6622 (2022), pp. 848–852.
References:
1. Caleb J Bashor et al. “Engineering the next generation of cell-based therapeutics”. In: Nature Reviews Drug Discovery 21.9 (2022), pp. 655–675. 2. Wendell A Lim. “The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function”. In: Science 378.6622 (2022), pp. 848–852.
The goal of this project is to engineer genetic circuits in human cells and establish cell lines for therapeutic applications. Within this task, the prospective student may explore different genetic topologies and develop various cell line engineering workflows and co-culture assays.
The ideal candidate should be highly motivated and able to work both in a group and independently. Although there are no mandatory requirements, basic expertise in cell culture, flow cytometry and cloning is desirable as well as some experience with mathematical modeling and numerical simulations.
The goal of this project is to engineer genetic circuits in human cells and establish cell lines for therapeutic applications. Within this task, the prospective student may explore different genetic topologies and develop various cell line engineering workflows and co-culture assays.
The ideal candidate should be highly motivated and able to work both in a group and independently. Although there are no mandatory requirements, basic expertise in cell culture, flow cytometry and cloning is desirable as well as some experience with mathematical modeling and numerical simulations.
For further information, please contact:
- Asterios Arampatzis (asterios.arampatzis@bsse.ethz.ch)
- Federica Cella (federica.cella@bsse.ethz.ch)
- Prof. Mustafa Khammash (mustafa.khammash@bsse.ethz.ch)
For further information, please contact:
- Asterios Arampatzis (asterios.arampatzis@bsse.ethz.ch) - Federica Cella (federica.cella@bsse.ethz.ch) - Prof. Mustafa Khammash (mustafa.khammash@bsse.ethz.ch)
