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Advanced manufacturing of drug delivery systems
In this project, we will use advanced manufacturing to produce drug delivery systems that can be use several clinical challenges such as micronutrients anaemia and type 2 diabetes.
Polymer formulation combined with advanced post-processing approaches will be used to scale up the production of drug delivery systems having specific release profile.
In vitro studies will be performed to characterize the efficiency of the produced drug delivery systems.
Keywords: Drug delivery, drug formulation, polymer/biomaterial design, advanced manufacturing
The project focuses on the development of an gastro-retentive drug delivery system designed to address two critical global health challenges, such as micronutrient anaemia and type 2 diabetes. By optimizing the formulation and production process, we aim to enhance the bioavailability and controlled release of therapeutic agents.
The research combines cutting-edge material science with biomedical engineering, focusing on polymer properties that enable precision in dosage control and targeted delivery. Different polymer formulations and combination of active compounds, processing parameters (e.g., 3D design), post-processing parameters (e.g., cross-linking) will be tested. Mechanical and chemical characterization of formulated materials will be performed (e.g., rheological, drug release kinetic, swelling properties, and stability of encapsulated active ingredients).
The ultimate goal is to develop a scalable, cost-effective solution that improves patient outcomes, making essential treatments more efficient and accessible.
In this project, the student(s) will be responsible to formulate advanced drug delivery systems having tailored release kinetic of the active pharmaceutical ingredients, and will be working on scaling the production. The first part of the project will focus on chemical synthesis and mechanical characterization of biomaterials. The second part of this project will focus on the in vitro characterization to test toxicity and efficiency of the fabricated system.
For this semester/master thesis, we are looking for an enterprising student with background in pharmaceutical science, chemistry, chemical engineering, biomedical engineering, material science or similar field. Previous experience in the lab is required. Experience in drug formulation, nanoparticles synthesis, polymer design is of advantage. Some of the project tasks can be tailored to the interests of the student.
The project focuses on the development of an gastro-retentive drug delivery system designed to address two critical global health challenges, such as micronutrient anaemia and type 2 diabetes. By optimizing the formulation and production process, we aim to enhance the bioavailability and controlled release of therapeutic agents.
The research combines cutting-edge material science with biomedical engineering, focusing on polymer properties that enable precision in dosage control and targeted delivery. Different polymer formulations and combination of active compounds, processing parameters (e.g., 3D design), post-processing parameters (e.g., cross-linking) will be tested. Mechanical and chemical characterization of formulated materials will be performed (e.g., rheological, drug release kinetic, swelling properties, and stability of encapsulated active ingredients).
The ultimate goal is to develop a scalable, cost-effective solution that improves patient outcomes, making essential treatments more efficient and accessible.
In this project, the student(s) will be responsible to formulate advanced drug delivery systems having tailored release kinetic of the active pharmaceutical ingredients, and will be working on scaling the production. The first part of the project will focus on chemical synthesis and mechanical characterization of biomaterials. The second part of this project will focus on the in vitro characterization to test toxicity and efficiency of the fabricated system.
For this semester/master thesis, we are looking for an enterprising student with background in pharmaceutical science, chemistry, chemical engineering, biomedical engineering, material science or similar field. Previous experience in the lab is required. Experience in drug formulation, nanoparticles synthesis, polymer design is of advantage. Some of the project tasks can be tailored to the interests of the student.
1) Formulate polymers suitable for the encapsulation of drugs
2) Optimize the production process to ensure consistent quality and performance.
3) Test the polymer’s efficacy in controlled drug release and bioavailability improvement.
4) Explore the scalability of the system for mass production and clinical application.
1) Formulate polymers suitable for the encapsulation of drugs 2) Optimize the production process to ensure consistent quality and performance. 3) Test the polymer’s efficacy in controlled drug release and bioavailability improvement. 4) Explore the scalability of the system for mass production and clinical application.
