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Mechanical regulation of musculoskeletal regeneration
Delayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice.
Impaired bone healing capacities associated with advanced age and osteoporosis with non-union rates of up to 20% are of major clinical relevance. In our ongoing studies we implement standardized femoral defect models in mice to study the mechano-molecular mechanisms governing load-induced bone adaptation and regeneration. Via multi-disciplinary approaches (e.g. _in vivo_ models, gene editing, imaging) we aim to improve our understanding of musculoskeletal mechanobiology and regeneration.
Dependent on the current needs and the student`s background,the following methods will be applied:
- histology
- micro-CT analyses
- microscopy
- gene expression analyses
Impaired bone healing capacities associated with advanced age and osteoporosis with non-union rates of up to 20% are of major clinical relevance. In our ongoing studies we implement standardized femoral defect models in mice to study the mechano-molecular mechanisms governing load-induced bone adaptation and regeneration. Via multi-disciplinary approaches (e.g. _in vivo_ models, gene editing, imaging) we aim to improve our understanding of musculoskeletal mechanobiology and regeneration.
Dependent on the current needs and the student`s background,the following methods will be applied:
The aim of this project is to establish and apply protocols for different analytical methods needed in ongoing projects within the In vivo Mechanomics team.
The aim of this project is to establish and apply protocols for different analytical methods needed in ongoing projects within the In vivo Mechanomics team.
Dr. Esther Wehrle, esther.wehrle@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller
Dr. Esther Wehrle, esther.wehrle@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller