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compagOs – An in-vitro bone organoid platform for biomaterials development and personalized medicine
Our goal is to establish a sophisticated technology platform for bioengineered bone to speed-up biomaterials development for bone tissue engineering and to predict drug response for patients suffering from bone diseases. Our tools are 3D printing, bioprinting, nanoparticles, hydrogels, time-lapsed image processing of micro-CT scans and object-oriented programming.
Strain mapping in 3D printed piezoelectric nanocomposite scaffolds using microstructural imaging.
We recently showed using time-lapsed micro-CT analysis and end-point histology that mineralization of collagenous extracellular matrix was impeded in scaffolds containing a large amount of barium titanate when cultured under cyclic loading in dynamic compression bioreactors. However, it was not shown yet how the electrical charge relates to the filler content of the piezoelectric nanoparticles or the dynamic loading regime. This project aims at analyzing the strain distribution within 3D printed piezoelectric nanocomposite scaffolds using digital volume correlation of micro-computed tomography images. The outcome of this project will enable to connect local cell-mediated mineralization in mechanically loaded piezoelectric scaffolds with the local mechanoenvironment.
Strain mapping in 3D printed piezoelectric nanocomposite scaffolds using microstructural imaging. We recently showed using time-lapsed micro-CT analysis and end-point histology that mineralization of collagenous extracellular matrix was impeded in scaffolds containing a large amount of barium titanate when cultured under cyclic loading in dynamic compression bioreactors. However, it was not shown yet how the electrical charge relates to the filler content of the piezoelectric nanoparticles or the dynamic loading regime. This project aims at analyzing the strain distribution within 3D printed piezoelectric nanocomposite scaffolds using digital volume correlation of micro-computed tomography images. The outcome of this project will enable to connect local cell-mediated mineralization in mechanically loaded piezoelectric scaffolds with the local mechanoenvironment.
The specific goals for the projects will be tailored to the student’s interest, expertise and ambition as well as project requirements.
The specific goals for the projects will be tailored to the student’s interest, expertise and ambition as well as project requirements.
Gian Nutal Schädli
giannutal.schaedli@hest.ethz.ch
https://www.linkedin.com/in/giannutal/
https://twitter.com/compagOs
Gian Nutal Schädli giannutal.schaedli@hest.ethz.ch https://www.linkedin.com/in/giannutal/ https://twitter.com/compagOs
Each year the IDEA League offers the students of its partner universities over 180 monthly grants for a short-term research exchange. In general, these grants are awarded based on academic merit. For more information visit http://idealeague.org/student-grant/