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Graphical analysis of biopsy probes during liver perfusion experiments
Analyzing tissue probes from pig liver perfusion experiments.
Keywords: image processing, medical engineering
It is known that the liver has the ability to regenerate. Liver resection (surgical removal of the diseased part of the liver) for the treatment of liver cancer has been carried out for a few decades but many tumors are inoperable because the removal of a too large piece of liver is fatal. In this context, therapeutic strategies for liver regeneration are being researched in which the growth of a healthy liver piece outside of the body is carried out until a sufficient size is reached, with subsequent transplantation and removal of the diseased part. To this end, an ex vivo liver perfusion machine is currently being developed to extend the viability of liver tissue outside of the body up to five days and allow its growth.
It is known that the liver has the ability to regenerate. Liver resection (surgical removal of the diseased part of the liver) for the treatment of liver cancer has been carried out for a few decades but many tumors are inoperable because the removal of a too large piece of liver is fatal. In this context, therapeutic strategies for liver regeneration are being researched in which the growth of a healthy liver piece outside of the body is carried out until a sufficient size is reached, with subsequent transplantation and removal of the diseased part. To this end, an ex vivo liver perfusion machine is currently being developed to extend the viability of liver tissue outside of the body up to five days and allow its growth.
During the liver perfusion experiments, multiple tissue samples are taken periodically and analyzed optically by specialists. Special stainingsare applied in order to highlight certain cell areas or tissue types. Depending on the current condition of the liver, different messages can be drawn from these stainings. A graphical method shall be established in e.g. MATLAB to quantify these stainingsoptically and objectively measure certain liver parameters.
During the liver perfusion experiments, multiple tissue samples are taken periodically and analyzed optically by specialists. Special stainingsare applied in order to highlight certain cell areas or tissue types. Depending on the current condition of the liver, different messages can be drawn from these stainings. A graphical method shall be established in e.g. MATLAB to quantify these stainingsoptically and objectively measure certain liver parameters.
Dustin Becker, ML H 14, +41 44 632 24 99, dbecker@ethz.ch
Dr. Martin Schuler, ML H 18, +41 44 632 24 92, martin.schuler@wysszurich.ch
Dr. Max Hefti, ML H 18, +41 44 632 45 06, max.hefti@wysszurich.ch
Dustin Becker, ML H 14, +41 44 632 24 99, dbecker@ethz.ch Dr. Martin Schuler, ML H 18, +41 44 632 24 92, martin.schuler@wysszurich.ch Dr. Max Hefti, ML H 18, +41 44 632 45 06, max.hefti@wysszurich.ch