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Molecular regulation of musculoskeletal regeneration
Impaired musculoskeletal regeneration is a major issue in the clinical setting. In order to better understand the complex molecular mechanisms involved in musculoskeletal regeneration, we integrate novel molecular analyses to our standardized preclinical defect models in mice.
Impaired musculoskeletal regeneration capacities associated with advanced age are of major clinical relevance. In our ongoing studies we supplement our standardized multi-disciplinary _in vivo_ studies with novel transcriptomics approaches to study the mechano-molecular mechanisms governing load-induced musculoskeletal regeneration.
Dependent on the project status and the student`s background,the following methods will be applied:
- laser-capture-microdissection
- gene expression analyses
- treatment protocols for single cell RNAseq + spatial transcriptomics
Impaired musculoskeletal regeneration capacities associated with advanced age are of major clinical relevance. In our ongoing studies we supplement our standardized multi-disciplinary _in vivo_ studies with novel transcriptomics approaches to study the mechano-molecular mechanisms governing load-induced musculoskeletal regeneration.
Dependent on the project status and the student`s background,the following methods will be applied:
- laser-capture-microdissection - gene expression analyses - treatment protocols for single cell RNAseq + spatial transcriptomics
The aim of this project is to establish and apply protocols for different molecular methods needed in ongoing projects on musculoskeletal regeneration within the In vivo Mechanomics team.
The aim of this project is to establish and apply protocols for different molecular methods needed in ongoing projects on musculoskeletal regeneration within the In vivo Mechanomics team.
Dr. Esther Wehrle, esther.wehrle@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller
Dr. Esther Wehrle, esther.wehrle@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller