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An in sillico investigation into the effect of vasculature growth and remodelling on bone mechano-regulation
The vasculature has in important influence on the bone homeostasis. Yet a deep understanding of this mechanism is missing. The aim of this project is to develop an in silico model capturing the interplay between vasculature remodelling and bone physiological activity.
Keywords: In silico model, Bone Remodelling, Vasculature, Simulation, Programming
The cells responsible for bone homeostasis receive nutrients and oxygen through the vasculature. In addition, the vasculature serves as a source and a sink for chemical signals. Yet _in silico_ models for remodelling currently do not consider the vasculature.
Moreover, there are not bone remodelling models that consider chemical transport through vasculature. Nevertheless, some models can be adapted for this target, for example Kirchhoff’s laws.
In the Laboratory of Bone Biomechanics, we have developed a multiscale multi-physics model for bone physiology. The objective of this project is to expand this model by including vasculature remodelling. To this purpose, it is essential to provide it with a model based upon reliable assumptions from a biological point of view. The student has to implement the model in Python or C++ language code and run the related numerical simulations. Therefore, it is required that the student has a good knowledge in programming in Python language.
The cells responsible for bone homeostasis receive nutrients and oxygen through the vasculature. In addition, the vasculature serves as a source and a sink for chemical signals. Yet _in silico_ models for remodelling currently do not consider the vasculature. Moreover, there are not bone remodelling models that consider chemical transport through vasculature. Nevertheless, some models can be adapted for this target, for example Kirchhoff’s laws. In the Laboratory of Bone Biomechanics, we have developed a multiscale multi-physics model for bone physiology. The objective of this project is to expand this model by including vasculature remodelling. To this purpose, it is essential to provide it with a model based upon reliable assumptions from a biological point of view. The student has to implement the model in Python or C++ language code and run the related numerical simulations. Therefore, it is required that the student has a good knowledge in programming in Python language.
In silico model of vasculature growth and remodelling in bone tissues
In silico model of vasculature growth and remodelling in bone tissues
Daniele Boaretti (daniele.boaretti@hest.ethz.ch) Institute for Biomechanics, ETH Zurich, Professorship Ralph Müller
Daniele Boaretti (daniele.boaretti@hest.ethz.ch) Institute for Biomechanics, ETH Zurich, Professorship Ralph Müller