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A gastrointestinal mucosa interface for prolonged theranostics
The surface of the gastrointestinal (GI) tract is covered by a mucosal membrane, consisting of enormous health-related biochemical, physiologic, and pathophysiologic information, and serving for nutrition exchange. Progress has been made to access the GI mucosa for diagnostics and therapeutics in clinical settings. However, it is still extremely challenging to build a biocompatible and robust GI mucosa interface enabling real-time, continuous, and minimally invasive interactions with human body, due to the constant GI motility, fast cellular turnover rate, limited cavity space and extremely chemical and biological environments
In the Traverso Laboratories at Brigham and Women’s Hospital (Harvard Medical School), We are exploring novel engineering approaches to develop robust mucosal interfaces for long-term deployment of micro-electronics/drug reservoirs/physical barriers in the GI tract.
Keywords: flexible electronics, ingestible robotics, GI retention
We are seeking highly motivated students to develop engineering strategies to enable long-term GI retention with minimal tissue damage. Outstanding candidates will primarily assist investigators working with Prof. Giovanni Traverso at the Brigham and Women’s Hospital (Harvard Medical School). The goal of this position is to develop both experimental and numerical strategies to explore the parameters of engineering devices, optimizing the mucosal retention capability.
We favor students who can fulfill 9-12 month commitments for their stay. Only in special situations will we consider shorter appointments. Students planning for a research exchange program, bachelor’s thesis, or master’s thesis are highly encouraged to apply. We are looking for students interested in a challenging, fast-paced, intellectually stimulating environment with a background in
• Mechanical and Electronical Engineering
• Materials Science and Engineering
• Chemical Engineering
• Biomedical Engineering
We are seeking highly motivated students to develop engineering strategies to enable long-term GI retention with minimal tissue damage. Outstanding candidates will primarily assist investigators working with Prof. Giovanni Traverso at the Brigham and Women’s Hospital (Harvard Medical School). The goal of this position is to develop both experimental and numerical strategies to explore the parameters of engineering devices, optimizing the mucosal retention capability.
We favor students who can fulfill 9-12 month commitments for their stay. Only in special situations will we consider shorter appointments. Students planning for a research exchange program, bachelor’s thesis, or master’s thesis are highly encouraged to apply. We are looking for students interested in a challenging, fast-paced, intellectually stimulating environment with a background in • Mechanical and Electronical Engineering • Materials Science and Engineering • Chemical Engineering • Biomedical Engineering
Due to the interdisciplinary nature of our research, an ideal candidate will have research background in heat and mass transfer, polymer science, mechanics and/or device design, but training to gain further skills will be available. Candidates with relevant experience in three or more of the following areas are preferred:
• Numerical simulation (e.g., COMSOL)
• Polymer (e.g., hydrogel) synthesis and characterization
• Device design (e.g., CAD, SolidWorks)
• Device manufacture (e.g., 3D printing, Laser cutting, Machining)
Due to the interdisciplinary nature of our research, an ideal candidate will have research background in heat and mass transfer, polymer science, mechanics and/or device design, but training to gain further skills will be available. Candidates with relevant experience in three or more of the following areas are preferred: • Numerical simulation (e.g., COMSOL) • Polymer (e.g., hydrogel) synthesis and characterization • Device design (e.g., CAD, SolidWorks) • Device manufacture (e.g., 3D printing, Laser cutting, Machining)
Interested candidates should send a curriculum vitae and transcript along with a brief description of their research interests and experience to Dr. Binbin Ying (bying@bwh.harvard.edu).
Interested candidates should send a curriculum vitae and transcript along with a brief description of their research interests and experience to Dr. Binbin Ying (bying@bwh.harvard.edu).