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Developing Phototunable Hydrogel Systems
Photochemical reactions are playing an increasing role in tissue engineering and biofabrication fields. Phototunable hydrogel with programmed properties that allow controlling cell behaviors spatiotemporally. This project aims to develop a series of photosensitive hydrogel precursors and study their structure-property relationship systematically.
Hydrogels are crosslinked, hydrophilic polymer networks that imbibe large amounts of water. Their physicochemical properties are similar to the native extracellular matrix (ECM) of soft biological tissues. Since cells within tissues are surrounded by a complex three-dimensional (3D) microenvironment that is remodeled over time, phototunable biomaterials which allow user-defined control of cells and their 3D milieu hold the promise to revolutionize the techniques in tissue engineering. With increasingly used of photosensitive hydrogel systems, motivates the development of new fundamental studies that enable innovative material designs based on specific requirements of biological research.
Hydrogels are crosslinked, hydrophilic polymer networks that imbibe large amounts of water. Their physicochemical properties are similar to the native extracellular matrix (ECM) of soft biological tissues. Since cells within tissues are surrounded by a complex three-dimensional (3D) microenvironment that is remodeled over time, phototunable biomaterials which allow user-defined control of cells and their 3D milieu hold the promise to revolutionize the techniques in tissue engineering. With increasingly used of photosensitive hydrogel systems, motivates the development of new fundamental studies that enable innovative material designs based on specific requirements of biological research.
The goal of this project: 1) Synthesizing a series of advanced photosensitive hydrogel systems and characterizing their physicochemical properties systematically. 2) Studying the application of formulated hydrogels in light-based 3D printing.
The goal of this project: 1) Synthesizing a series of advanced photosensitive hydrogel systems and characterizing their physicochemical properties systematically. 2) Studying the application of formulated hydrogels in light-based 3D printing.
Wanwan Qiu (wanwan.qiu@hest.ethz.ch) Institute for Biomechanics, ETH Zurich, Professorship Ralph Müller
Wanwan Qiu (wanwan.qiu@hest.ethz.ch) Institute for Biomechanics, ETH Zurich, Professorship Ralph Müller