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Development of new fluorescent nanoparticles for bioimaging
Fluorescent nanomaterials can be used for non-invasive imaging of biological tissue. However, the currently available materials do not yet meet the requirements for deep-tissue imaging. Therefore, this projects aims to develop novel luminescent nanoparticles operating in the near-infrared region.
Keywords: fluorescence
luminescence
imaging
bioimaging
nanoparticles
near-infrared
medical
biomedical
diagnostics
in vitro
interdisciplinary
Imaging of biological tissue such as small animal imaging with the use of luminescent imaging agents is an upcoming technique that does not harm the body, in contrast to methods using ionizing radiation (e.g., x-rays, y-rays). However, the strong absorption of visible light by biological tissue has limited the application of this technique to very superficial tissue, such as skin. In contrast, near-infrared light (750-1500 nm) can penetrate much deeper into tissue, allowing improved imaging depth and resolution in bioimaging.
The goal of this project is to develop new nanomaterials with strong luminescence in the near-infrared via flame spray pyrolysis. Besides material optimization, also the functionalization of these particles to ensure their biocompatibility and/or specific targeting is crucial.
Imaging of biological tissue such as small animal imaging with the use of luminescent imaging agents is an upcoming technique that does not harm the body, in contrast to methods using ionizing radiation (e.g., x-rays, y-rays). However, the strong absorption of visible light by biological tissue has limited the application of this technique to very superficial tissue, such as skin. In contrast, near-infrared light (750-1500 nm) can penetrate much deeper into tissue, allowing improved imaging depth and resolution in bioimaging. The goal of this project is to develop new nanomaterials with strong luminescence in the near-infrared via flame spray pyrolysis. Besides material optimization, also the functionalization of these particles to ensure their biocompatibility and/or specific targeting is crucial.
Specific goals will be set in collaboration with the perspective student, specifically tailored to his background, time frame and preferences.
Specific goals will be set in collaboration with the perspective student, specifically tailored to his background, time frame and preferences.