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Investigation of brain connectivity and cerebrovascular dysfunctions in Alzheimer's disease mouse models
In this project, we aim to analyze tauopathy-driven changes in cerebrovascular function, hemodynamics, brain connectivity and neurodegeneration in Alzheimer's disease tauopathy mouse models by using high-resolution MRI and photoacoustic tomography.
Emerging evidence suggests that tauopathy independent of amyloid-beta deposits may play a role in the aberrant cerebrovasculature and functional connectivity in Alzheimer’s disease. Here we aim to analyze tauopathy induced changes in cerebrovascular function, hemodynamics, connectivity and brain volume in a tauopathy mouse model. The advances in neuroimaging such as high resolution functional magnetic resonance imaging (MRI) provide valuable tools for understanding brain connectivity and pathophysiology in the living brain. Novel photoacoustic tomography provides 3D in vivo visualization of brain hemodynamics. Student will investigate the cerebrovascular, heamodynamic and pathphyiological alterations in brain of tauopathy mouse model, by using high-resolution functional MRI, photoacoustic tomography and confocal microscopy.
The project consists 25% experiment, 50% analysis, 10% reading 15% report/thesis writing. Seminars in the group and organized by institute of Biomedical engineering every week provide state-of art imaging acquisition and analysis methods.
Emerging evidence suggests that tauopathy independent of amyloid-beta deposits may play a role in the aberrant cerebrovasculature and functional connectivity in Alzheimer’s disease. Here we aim to analyze tauopathy induced changes in cerebrovascular function, hemodynamics, connectivity and brain volume in a tauopathy mouse model. The advances in neuroimaging such as high resolution functional magnetic resonance imaging (MRI) provide valuable tools for understanding brain connectivity and pathophysiology in the living brain. Novel photoacoustic tomography provides 3D in vivo visualization of brain hemodynamics. Student will investigate the cerebrovascular, heamodynamic and pathphyiological alterations in brain of tauopathy mouse model, by using high-resolution functional MRI, photoacoustic tomography and confocal microscopy.
The project consists 25% experiment, 50% analysis, 10% reading 15% report/thesis writing. Seminars in the group and organized by institute of Biomedical engineering every week provide state-of art imaging acquisition and analysis methods.
to understand the taupathy-driven alterations in brain connectivity, cerebrovascular function, and brain volume using multimodal imaging
to understand the taupathy-driven alterations in brain connectivity, cerebrovascular function, and brain volume using multimodal imaging
Dr. Ruiqing Ni, ni@biomed.ee.ethz.ch
Prof. Jan Klohs, klohs@biomed.ee.ethz.ch
Institute of Biomedical Engineering ETH Zurich & University of Zurich HIT E 22.4 Wolfgang-Pauli-Str. 27 8093 Zurich
Dr. Ruiqing Ni, ni@biomed.ee.ethz.ch Prof. Jan Klohs, klohs@biomed.ee.ethz.ch Institute of Biomedical Engineering ETH Zurich & University of Zurich HIT E 22.4 Wolfgang-Pauli-Str. 27 8093 Zurich
Each year the IDEA League offers the students of its partner universities over 180 monthly grants for a short-term research exchange. In general, these grants are awarded based on academic merit. For more information visit http://idealeague.org/student-grant/