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Characterization of acoustic droplet vaporization parameters using a clinical ultrasound probe
Acoustic Droplet Vaporization is the phase-change process of superheated droplets (usually micrometric or nanometric in size) triggered by the exposure to an ultrasound wave. This phenomenon can be greatly exploited in the biomedical field, and ultrasound imaging is an effective way to study and characterize it.
Acoustic Droplet Vaporization (ADV) is a novel acoustic technique where the phase-change of micron sized liquid droplets into microbubbles is initiated using an ultrasound wave. This phenomenon has been studied in the last years due to its promising performance in many biomedical applications such as contrast enhanced imaging, embolotherapy, targeted drug delivery, to name a few. The vaporization process can be viewed using a conventional biomedical ultrasound system, but it does not allow for much user tunability in terms of properties of the transmitting acoustic waves and data processing techniques, which makes it difficult to properly compare the various results obtained from different equipment in literature and perform systematic parametric studies.
ULtrasound Advanced-Open Platform (ULA-OP) is an open platform ultrasound system which can interface with clinical ultrasound probes. The platform itself allows for a large degree of control on both the transmitted signal and the processing of the received one.
Acoustic Droplet Vaporization (ADV) is a novel acoustic technique where the phase-change of micron sized liquid droplets into microbubbles is initiated using an ultrasound wave. This phenomenon has been studied in the last years due to its promising performance in many biomedical applications such as contrast enhanced imaging, embolotherapy, targeted drug delivery, to name a few. The vaporization process can be viewed using a conventional biomedical ultrasound system, but it does not allow for much user tunability in terms of properties of the transmitting acoustic waves and data processing techniques, which makes it difficult to properly compare the various results obtained from different equipment in literature and perform systematic parametric studies.
ULtrasound Advanced-Open Platform (ULA-OP) is an open platform ultrasound system which can interface with clinical ultrasound probes. The platform itself allows for a large degree of control on both the transmitted signal and the processing of the received one.
The goal of this project is to methodically study the vaporization threshold of a monodispersed droplet population by varying the relevant parameter such as excitation wave frequency, amplitude and pulse length. Both the acoustic driving and the imaging will be performed using the ULA-OP system. The postprocessing techniques may involve B-Mode, Doppler and Power Spectrum analysis. The project will also include microfluidic generation of different sized monodisperse droplet samples (perfluoropentane droplets with a size range of 5 – 20 µm in diameter).
The goal of this project is to methodically study the vaporization threshold of a monodispersed droplet population by varying the relevant parameter such as excitation wave frequency, amplitude and pulse length. Both the acoustic driving and the imaging will be performed using the ULA-OP system. The postprocessing techniques may involve B-Mode, Doppler and Power Spectrum analysis. The project will also include microfluidic generation of different sized monodisperse droplet samples (perfluoropentane droplets with a size range of 5 – 20 µm in diameter).
For further information, please contact Dr. Gazendra Shakya (gshakya@ethz.ch) or Samuele Fiorini (sfiorini@ethz.ch) via email.
For further information, please contact Dr. Gazendra Shakya (gshakya@ethz.ch) or Samuele Fiorini (sfiorini@ethz.ch) via email.