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Master thesis: How 2 neurones control longevity through dietary restriction
Previously, 2 neurons have been shown to be required for organismal longevity under dietary restriction via the transcription factor SKN-1 in C. elegans doi:10.1038/nature05904. However, the mechanism how these neurons communicate with the peripheral tissue to improve health during aging is unknown
We are looking for a master student with neuroscience or molecular biology background. Candidate must be in the ETH Masters program. No experience with C. elegans required. Experience in microscopy and cloning welcomed. The candidate will learn molecular techniques including DAM-ID and CRISPR.
We are looking for a master student with neuroscience or molecular biology background. Candidate must be in the ETH Masters program. No experience with C. elegans required. Experience in microscopy and cloning welcomed. The candidate will learn molecular techniques including DAM-ID and CRISPR.
The master student will implement neuronal-specific DAM-ID to determine SKN-1 downstream target genes. This will generate hypothesis of the signalling molecule from the neurones to the peripheral tissue. Candidate genes will be assessed for their requirement with the lifespan assays.
The master student will implement neuronal-specific DAM-ID to determine SKN-1 downstream target genes. This will generate hypothesis of the signalling molecule from the neurones to the peripheral tissue. Candidate genes will be assessed for their requirement with the lifespan assays.
Please, send CV, a paragraph explaining your motivation working on this project and highlighting your skills. Please, email at collin-ewald(at)ethz.ch For more info please visit: www.ewaldlab.com
Please, send CV, a paragraph explaining your motivation working on this project and highlighting your skills. Please, email at collin-ewald(at)ethz.ch For more info please visit: www.ewaldlab.com