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Development of novel biosensor
I have a number of Master Thesis projects on Focal Molography. Molography is a novel method for the analysis of biomolecular interactions with unprecedented robustness and sensitivity.
Keywords: early detection, genetics, antibody, peptide, cell, bio molecule, cancer, drug discovery, optics, photonics, micro biology, biomedical
Current label-free biosensors such as surface plasmon resonance (SPR) or optical waveguide lightmode spectroscopy (OWLS) are extremely sensitive, yet they suffer inherent drawbacks. Fluctuations in temperature and buffer composition as well as false positive detection of superabundant background molecules render these technologies inapplicable for early diagnosis. Recently introduced, Focal Molography reaches comparable levels of sensitivity as SPR without any of the aforementioned limitations. Id est, Molography is inherently insensitive to nonspecific binding, medium composition, and solvent exchanges. Thus, it is highly interesting for studying molecular interactions, real-time in blood and other complex samples that are challenging or impossible to measure with any other technique. In our lab at ETH we investigate Focal Molography in all its details, from optical simulations to waveguide optimization as well as novel assays and drug discovery. Figure 1 shows the working principle of Molography. Briefly, coherent light is scattered at coherently assembled molecules which are linked to a biocompatible monolithic layer on the surface of a chip. The scattered light constructively interferes into a diffraction limited focal spot. The reason for the robustness of this technology lies in the fact that only coherently arranged molecules contribute to the molographic signal. Unspecifically adsorbed molecules do not contribute to the the molographic signal.
Current label-free biosensors such as surface plasmon resonance (SPR) or optical waveguide lightmode spectroscopy (OWLS) are extremely sensitive, yet they suffer inherent drawbacks. Fluctuations in temperature and buffer composition as well as false positive detection of superabundant background molecules render these technologies inapplicable for early diagnosis. Recently introduced, Focal Molography reaches comparable levels of sensitivity as SPR without any of the aforementioned limitations. Id est, Molography is inherently insensitive to nonspecific binding, medium composition, and solvent exchanges. Thus, it is highly interesting for studying molecular interactions, real-time in blood and other complex samples that are challenging or impossible to measure with any other technique. In our lab at ETH we investigate Focal Molography in all its details, from optical simulations to waveguide optimization as well as novel assays and drug discovery. Figure 1 shows the working principle of Molography. Briefly, coherent light is scattered at coherently assembled molecules which are linked to a biocompatible monolithic layer on the surface of a chip. The scattered light constructively interferes into a diffraction limited focal spot. The reason for the robustness of this technology lies in the fact that only coherently arranged molecules contribute to the molographic signal. Unspecifically adsorbed molecules do not contribute to the the molographic signal.
I have a number of Master Tesis projects available. The details of these projects are confidential and are thus not shown here. Please write me an email or come and meet me in the lab for a coffee and I will tell you more about it.
I have a number of Master Tesis projects available. The details of these projects are confidential and are thus not shown here. Please write me an email or come and meet me in the lab for a coffee and I will tell you more about it.
I (Andreas Reichmuth) am a PhD Student at the Laboratory for Biosensors and Bioelectronics (LBB) at ETH Zürich. The lab is part of D-ITET in ETH Zentrum. We have a very relaxed atmosphere, dedicated office for Master students, and free coffee for students doing a project with us (using possibly the best coffee machine at ETH)!
I (Andreas Reichmuth) am a PhD Student at the Laboratory for Biosensors and Bioelectronics (LBB) at ETH Zürich. The lab is part of D-ITET in ETH Zentrum. We have a very relaxed atmosphere, dedicated office for Master students, and free coffee for students doing a project with us (using possibly the best coffee machine at ETH)!