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(NOT AVAILABLE ANYMORE) Manufacturing and testing of devices for separation of circulating tumor cells
Manufacturing and testing of devices for separation of circulating tumor cells. Unfortunately the current project is already promised to another student. There are however always opportunities for motivated students interested in the technology.
Metastatic spreading is the primary cause of tumor-related death. In case of bone cancer, particularly devastating to patients and patient families since it primarily affects children and adolescents, this dissemination of cancerous cells to distant sites occurs through the bloodstream and accordingly metastasizing cells (also known as 'circulating tumor cells' or CTCs) can be found in peripheral blood of patients. A project in the labs of Prof. Dual and Prof. Snedeker aims to develop a new microfluidic system for the label-free isolation of CTCs and for their subsequent biophysical analysis.
This thesis would be comprised of the testing of bulk acoustic waves and thin film bulk acoustic wave devices prefabricated in the lab and if time and knowledge permits, the development of own devices. These devices would be tested with multiple different samples such as polystyrene beads, single cell populations and eventually blood samples.
Metastatic spreading is the primary cause of tumor-related death. In case of bone cancer, particularly devastating to patients and patient families since it primarily affects children and adolescents, this dissemination of cancerous cells to distant sites occurs through the bloodstream and accordingly metastasizing cells (also known as 'circulating tumor cells' or CTCs) can be found in peripheral blood of patients. A project in the labs of Prof. Dual and Prof. Snedeker aims to develop a new microfluidic system for the label-free isolation of CTCs and for their subsequent biophysical analysis. This thesis would be comprised of the testing of bulk acoustic waves and thin film bulk acoustic wave devices prefabricated in the lab and if time and knowledge permits, the development of own devices. These devices would be tested with multiple different samples such as polystyrene beads, single cell populations and eventually blood samples.
• A comprehensive literature research
• Training in methods of blood and cell sample handling
• Training in biological methods such as immunofluorescent staining and blood lysis
• Training on different systems for characterization, such as deformability cytometry and microscale acoustofluidics
• Written report
• A comprehensive literature research • Training in methods of blood and cell sample handling • Training in biological methods such as immunofluorescent staining and blood lysis • Training on different systems for characterization, such as deformability cytometry and microscale acoustofluidics • Written report