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Evaluation of adhesion strategies for intervertebral disk repair via electrospun polycaprolactone scaffolds
The project is placed in the scope of a larger study on inter-vertebral disc regeneration. Small defects in intevetebral disks often lead to further degradation and a need for complete replacement of the organ. To allow for self healing of larger defects a support structure of electrospun polycapro
In this project the student will investigate different approaches including bio glues and various geometries of mechanical fixation of electrospun scaffolds on live intervertebral disk tissue. The project will involve isolation of tissue samples, and preparation for testing. Electrospun scaffolds will be provided or produced in house. The optimal strategy will be initially identified through visual inspection and optical imaging methods. If a successful strategy is found, the second stage of the project will involve extensive mechanical testing under biomechanically relevant conditions.
The project will entail working on mechanical testing equipment as well as live tissue preparation, handling and bio viability evaluation.
In this project the student will investigate different approaches including bio glues and various geometries of mechanical fixation of electrospun scaffolds on live intervertebral disk tissue. The project will involve isolation of tissue samples, and preparation for testing. Electrospun scaffolds will be provided or produced in house. The optimal strategy will be initially identified through visual inspection and optical imaging methods. If a successful strategy is found, the second stage of the project will involve extensive mechanical testing under biomechanically relevant conditions. The project will entail working on mechanical testing equipment as well as live tissue preparation, handling and bio viability evaluation.
• Prepare representative samples of IVD tissue from bovine tail sections.
• Prepare electrospun scaffolds for implantation.
• Identify various strategies for mechanical fixation.
• Test the strategies through mechanical testing and imaging techniques (SEM, optical).
• Prepare representative samples of IVD tissue from bovine tail sections. • Prepare electrospun scaffolds for implantation. • Identify various strategies for mechanical fixation. • Test the strategies through mechanical testing and imaging techniques (SEM, optical).
Dmitriy Alexeev
ETH Zürich, Institut für Biomechanik
HPP O 14, Hönggerbergring 64
8093 Zürich, Switzerland
Email: dmitriy.alexeev@hest.ethz.ch
Tel: +41 44 633 29 40
Dmitriy Alexeev ETH Zürich, Institut für Biomechanik HPP O 14, Hönggerbergring 64 8093 Zürich, Switzerland Email: dmitriy.alexeev@hest.ethz.ch Tel: +41 44 633 29 40