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Acoustofluidic patterning cells for skin fabrication
Skin is one of the largest organs in our body and has diverse functions. Various research groups in Zurich are actively pursuing skin tissue engineering and study of skin related diseases under the umbrella of SKINTEGRITY. Generally, skin fabrication ex vivo is done by platting cells (fibroblasts, k
Keywords: skin, acoustofluidics
In this project, we would develop a device for patterning cells during the fabrication of skin models. This could be of particular interest to include vasculature network or for study of disease progression in these skin models.
The device will use acoustofluidics to position cells of interest during cell seeding. Acoustofluidics relies on the force that manipulates particles towards the pressure nodes or antinodes of a standing wave pressure field created within a fluidic channel. Acoustofluidics has emerged as a contactless, safe, and label-free method to manipulate mammalian cells in 3D space through induced pressure waves within a fluid.
In this project, we would develop a device for patterning cells during the fabrication of skin models. This could be of particular interest to include vasculature network or for study of disease progression in these skin models. The device will use acoustofluidics to position cells of interest during cell seeding. Acoustofluidics relies on the force that manipulates particles towards the pressure nodes or antinodes of a standing wave pressure field created within a fluidic channel. Acoustofluidics has emerged as a contactless, safe, and label-free method to manipulate mammalian cells in 3D space through induced pressure waves within a fluid.