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Body-on-a-chip: 3D microtissue handling and analysis in microfluidic systems
Multi-cellular spheroids or microtissues become more and more important as 3-dimensional disease models that can be exploited for preclinical drug efficacy and toxicity testing. With the advantage to be closer to the natural 3-dimensional cell structure, they are easy to handle and integrate into mi
Keywords: Microfluidics, Microphysiological Systems, 3D Cell Culture, Spheroids, Organoids, Body on a Chip, Microfabrication, Microscopy, Biosensors
Novel approaches of microfluidic networks are developed that allow hosting and analyzing microtissue structures in long-term culturing experiments. This includes microtissue loading, their immobilization at defined sites and release for post-experimental analysis. Further, microfluidic functions (pumping, liquid sampling) as well as sensor systems (biosensors, impedance spectroscopy) are integrated. Tasks consist in designing and fabrication of microfluidic devices using dedicated software and in-house cleanroom facilities, thorough validation of the devices with 3D microtissues of different cell types und basic drug screening and toxicity testing experiments.
Novel approaches of microfluidic networks are developed that allow hosting and analyzing microtissue structures in long-term culturing experiments. This includes microtissue loading, their immobilization at defined sites and release for post-experimental analysis. Further, microfluidic functions (pumping, liquid sampling) as well as sensor systems (biosensors, impedance spectroscopy) are integrated. Tasks consist in designing and fabrication of microfluidic devices using dedicated software and in-house cleanroom facilities, thorough validation of the devices with 3D microtissues of different cell types und basic drug screening and toxicity testing experiments.
**You learn**
- Working with 3D tissue cultures
- Microfluidic chip design, fabrication and operation
- Microsensor design and implementation
- Biochemical assays
- Life-cell microscopy
**You learn** - Working with 3D tissue cultures - Microfluidic chip design, fabrication and operation - Microsensor design and implementation - Biochemical assays - Life-cell microscopy
Dr. Patrick Misun
patrick.misun@bsse.ethz.ch
+41 61 387 33 70
Dr. Patrick Misun patrick.misun@bsse.ethz.ch +41 61 387 33 70