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Digital Therapy for Healthcare: inverse treatment planning
Recent mini-invasive procedures are introduced for the treatment of tumors or heart tissue using devices based on thermal or electric irreversible treatment. To create a standard proof-of-concept of their application as established techniques, several challenges about their effectiveness are unmet.
The project has multiple-aim that could be investigated by the candidate:
1. Quantify the effectiveness of treatment: develop a bio-engineering model that couple the tissue remodeling and vascularization net, cancer invasion/ heart electro-physiology with the effect of external device
2. Quantify the pulse and position of devices respect to cancer dimensions and electroporation status of the tissue : develop a control problem associated to bioengineering modeling and validate with in-vitro data
**References
**
00van den Bos W, Jurhill RR, de Bruin DM et al (2016) Histopathological outcomes after irreversible electroporation in prostate cancer; results of an ablate-and-resect study. J Urol. doi:10.1016/j.juro.2016.02.2977
Angiodynamics Website: http://www.angiodynamics.com/products/nanoknife
Garcia PA, Davalos RV, Miklavčič D (2014) A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue. PLoS One 9(8):e103083
Kos B, Voigt P, Miklavčič D, Moche M (2015) Careful treatment planning enables safe ablation of liver tumors adjacent to major blood vessels by percutaneous irreversible electroporation (IRE). Radiol Oncol 49:234–241
Irreversible Electroporation: Background, Theory, and Review of Recent Developments in Clinical Oncology, Kenneth N. Aycock and Rafael V. Davalos.Bioelectricity.Dec 2019.214-234.http://doi.org/10.1089/bioe.2019.0029
The project has multiple-aim that could be investigated by the candidate:
1. Quantify the effectiveness of treatment: develop a bio-engineering model that couple the tissue remodeling and vascularization net, cancer invasion/ heart electro-physiology with the effect of external device
2. Quantify the pulse and position of devices respect to cancer dimensions and electroporation status of the tissue : develop a control problem associated to bioengineering modeling and validate with in-vitro data
**References ** 00van den Bos W, Jurhill RR, de Bruin DM et al (2016) Histopathological outcomes after irreversible electroporation in prostate cancer; results of an ablate-and-resect study. J Urol. doi:10.1016/j.juro.2016.02.2977 Angiodynamics Website: http://www.angiodynamics.com/products/nanoknife Garcia PA, Davalos RV, Miklavčič D (2014) A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue. PLoS One 9(8):e103083 Kos B, Voigt P, Miklavčič D, Moche M (2015) Careful treatment planning enables safe ablation of liver tumors adjacent to major blood vessels by percutaneous irreversible electroporation (IRE). Radiol Oncol 49:234–241
Irreversible Electroporation: Background, Theory, and Review of Recent Developments in Clinical Oncology, Kenneth N. Aycock and Rafael V. Davalos.Bioelectricity.Dec 2019.214-234.http://doi.org/10.1089/bioe.2019.0029
Provide a in-Silico proof-of-concept for oncology devices. The project is in collaboration with Philips digital scientists and RWTH Clinic
Provide a in-Silico proof-of-concept for oncology devices. The project is in collaboration with Philips digital scientists and RWTH Clinic
baroli@aices.rwth-aachen.de (PostDoc at RWTH, co-PI of ElectroPros ITN MSCA)
baroli@aices.rwth-aachen.de (PostDoc at RWTH, co-PI of ElectroPros ITN MSCA)