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Spatial molecular analysis of tissue sections using microfluidic probe
Every organism is an expression of the fine balance between order and chaos. Tumor biology, not being exempt from this complexity, expresses ‘chaos’ in the form of heterogeneity, and overlooking it by averaging data across whole tumors often makes profiles inaccurate and their treatment ineffective. We aim to address this challenge from a technological perspective.
Keywords: spatial profiling, molecular profiling, microfluidics, biomedical engineering, lab on a chip
The primary task of the thesis is to develop assays and analytics for biomarker discovery integrating spatial lysis with DNA and protein microarray techniques. Specifically, the student will • Develop/adapt current microscale lysis assays for profiling the genome and proteome by delivering them onto commercially available DNA and proteomic microarray panels. • Develop the assay for both targeted (clinically relevant) and discovery based downstream analysis. • Develop metrics for quantitative evaluation of heterogeneity within tumor tissue sections.
The student must be strong in one of the following disciplines: biomedical engineering or molecular/cell biology or chemistry with some experience in bioinformatics. The student must be motivated, self-driven and keen to work in an interdisciplinary environment.
Not specified
Not specified
Jan/Feb 2021
Jan/Feb 2021
Please send an e-mail to Govind Kaigala (gov@zurich.ibm.com)
Please send an e-mail to Govind Kaigala (gov@zurich.ibm.com)