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Exploring the Mechanoregulation of Bone Regeneration
In over 100 years, the remarkable ability of bone to adapt to its mechanical environment has been a source of scientific fascination. Bone regeneration has been shown to be highly dependent on the mechanical environment at the fracture site. It has been demonstrated that mechanical stimuli can either accelerate or impede regeneration. Despite the fundamental importance of the mechanical environment in influencing bone regeneration, the molecular mechanisms underlying this phenomenon are complex and poorly understood.
To address this century-old problem, the Laboratory for Bone Biomechanics has established a novel approach termed “spatial mechanomics”. Spatial mechanomics is defined as the integration of spatially-resolved “omics” with in silico models of the mechanical environment to investigate the interactions between local mechanical environments and cellular / molecular responses (Figure 1).
This is a highly cross-disciplinary area of research combining in vivo models, imaging, “omics” techniques, mechanical testing and computational modelling / analyses. There are opportunities for student projects within this area of research that can be tailored to suitable candidates. Ideally applicants will be candidates with an interest or experience in musculoskeletal research, “omics” techniques, computational analyses, mechanical engineering, histology and/or image processing.
To address this century-old problem, the Laboratory for Bone Biomechanics has established a novel approach termed “spatial mechanomics”. Spatial mechanomics is defined as the integration of spatially-resolved “omics” with in silico models of the mechanical environment to investigate the interactions between local mechanical environments and cellular / molecular responses (Figure 1).
This is a highly cross-disciplinary area of research combining in vivo models, imaging, “omics” techniques, mechanical testing and computational modelling / analyses. There are opportunities for student projects within this area of research that can be tailored to suitable candidates. Ideally applicants will be candidates with an interest or experience in musculoskeletal research, “omics” techniques, computational analyses, mechanical engineering, histology and/or image processing.
We are interested in the following:
• To develop a molecular-based understanding of bone healing mechanobiology.
• To investigate how this mechano-sensitivity is compromised with age.
We are interested in the following:
• To develop a molecular-based understanding of bone healing mechanobiology.
• To investigate how this mechano-sensitivity is compromised with age.
