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Development of drug delivery wet dressing for localized treatment of psoriasis
Psoriasis is a chronic skin disorder addressed mainly with inefficient topical treatments. Here we propose a wet dressing to control the release of nanosized particles able to penetrate the dermis and provide a localized action of drugs through the use of functionalized electrospun fibers.
Keywords: drug delivery, biomaterials, nanoparticles, electrospinning
Nanoparticles are versatile systems able to entrap a wide variety of drugs, to provide high control over the release profile and to elicit a targeted action through surface functionalization. Combining electrospinning techniques and nanoparticles formulation, this project aims to steer the release of drug, targeting specific cells and deactivating tool-like receptors responsible for the psoriasis outbreak.
Nanoparticles are versatile systems able to entrap a wide variety of drugs, to provide high control over the release profile and to elicit a targeted action through surface functionalization. Combining electrospinning techniques and nanoparticles formulation, this project aims to steer the release of drug, targeting specific cells and deactivating tool-like receptors responsible for the psoriasis outbreak.
1. Optimization of nanosized particles formulation embedding GFPs and assessment of their stability over time.
2. Surface functionalization for targeting tool-receptors on psoriatic cells and evaluation of the efficiency of the binding.
3. Embedding of active drugs and assessment of loading efficiency and release profile.
3. Electrospinning of polymeric fibers and characterization of the degradation behaviour.
5. Electrospinning of core-sheath fibers embedding nanosized drug-carrying nanoparticles in the core, release study of the whole system in vitro(fibers+particles).
The position is for a 6 months project. It is part a of a Marie-Curie fellowship and is open for students with a background in chemical and biomedical engineering, chemistry and material science.
1. Optimization of nanosized particles formulation embedding GFPs and assessment of their stability over time. 2. Surface functionalization for targeting tool-receptors on psoriatic cells and evaluation of the efficiency of the binding. 3. Embedding of active drugs and assessment of loading efficiency and release profile. 3. Electrospinning of polymeric fibers and characterization of the degradation behaviour. 5. Electrospinning of core-sheath fibers embedding nanosized drug-carrying nanoparticles in the core, release study of the whole system in vitro(fibers+particles).
The position is for a 6 months project. It is part a of a Marie-Curie fellowship and is open for students with a background in chemical and biomedical engineering, chemistry and material science.