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Chemical sensing platform for in-situ and real-time monitoring of wound healing process
Chronic wounds (i.e. venous, diabetic ulcers) are regarded as a silent epidemic, which affects 1-2% of the population and represent 2-4% of healthcare expenses. On the other side, approximately 900 mil-lion people suffer worldwide from acute injuries (i.e. penetrating trauma, burns) requiring specia
Chronic wounds (i.e. venous, diabetic ulcers) are regarded as a silent epidemic, which affects 1-2% of the population and represent 2-4% of healthcare expenses. On the other side, approximately 900 mil-lion people suffer worldwide from acute injuries (i.e. penetrating trauma, burns) requiring specialized healthcare. Beside the improved guidelines and therapies, chronic and acute wound management remains extremely challenging. Due to the inherent complexity of the healing process and the gap in evidence-based wound management method, wound management is based on non-optimal treat-ments that rely on trial-and-error approaches and unnecessary medical interventions.
This work will be part of a PHRT project called WoundSense which aims to develop non-invasive multi-sensing platform integrated on polymeric optical fibers, for an in-situ and real-time monitoring of me-tabolites in wound exudate (e.g. pH, glucose, metalloproteinase, etc.). The final device will allow to ob-jectively assess seriousness of the wound, promptly defining the better treatment and monitoring the wound healing process.
During the master project, the student will be guided through all steps required for the development of sensing platforms: design, synthesis, characterization and evaluation. The student will learn funda-mental aspects of chemistry and fabrication of nanomaterials beside being introduces to the main characterization approaches. However, the experience will be mainly focused on the evaluation of the chemical sensing platform in its selectivity and sensitivity in detecting the targeted metabolite. Hence the student will achieve confidence with analytical techniques such as UV-Vis and fluorescence spec-trophotometry. The selected student can expect significant support and guidance from established scientists during the whole duration of the project. Work place will be the Empa St. Gallen.
Chronic wounds (i.e. venous, diabetic ulcers) are regarded as a silent epidemic, which affects 1-2% of the population and represent 2-4% of healthcare expenses. On the other side, approximately 900 mil-lion people suffer worldwide from acute injuries (i.e. penetrating trauma, burns) requiring specialized healthcare. Beside the improved guidelines and therapies, chronic and acute wound management remains extremely challenging. Due to the inherent complexity of the healing process and the gap in evidence-based wound management method, wound management is based on non-optimal treat-ments that rely on trial-and-error approaches and unnecessary medical interventions.
This work will be part of a PHRT project called WoundSense which aims to develop non-invasive multi-sensing platform integrated on polymeric optical fibers, for an in-situ and real-time monitoring of me-tabolites in wound exudate (e.g. pH, glucose, metalloproteinase, etc.). The final device will allow to ob-jectively assess seriousness of the wound, promptly defining the better treatment and monitoring the wound healing process.
During the master project, the student will be guided through all steps required for the development of sensing platforms: design, synthesis, characterization and evaluation. The student will learn funda-mental aspects of chemistry and fabrication of nanomaterials beside being introduces to the main characterization approaches. However, the experience will be mainly focused on the evaluation of the chemical sensing platform in its selectivity and sensitivity in detecting the targeted metabolite. Hence the student will achieve confidence with analytical techniques such as UV-Vis and fluorescence spec-trophotometry. The selected student can expect significant support and guidance from established scientists during the whole duration of the project. Work place will be the Empa St. Gallen.
During the master project, the student will be guided through all steps required for the development of sensing platforms: design, synthesis, characterization and evaluation. The student will learn funda-mental aspects of chemistry and fabrication of nanomaterials beside being introduces to the main characterization approaches. However, the experience will be mainly focused on the evaluation of the chemical sensing platform in its selectivity and sensitivity in detecting the targeted metabolite. Hence the student will achieve confidence with analytical techniques such as UV-Vis and fluorescence spec-trophotometry. The selected student can expect significant support and guidance from established scientists during the whole duration of the project. Work place will be the Empa St. Gallen.
During the master project, the student will be guided through all steps required for the development of sensing platforms: design, synthesis, characterization and evaluation. The student will learn funda-mental aspects of chemistry and fabrication of nanomaterials beside being introduces to the main characterization approaches. However, the experience will be mainly focused on the evaluation of the chemical sensing platform in its selectivity and sensitivity in detecting the targeted metabolite. Hence the student will achieve confidence with analytical techniques such as UV-Vis and fluorescence spec-trophotometry. The selected student can expect significant support and guidance from established scientists during the whole duration of the project. Work place will be the Empa St. Gallen.
Dr. Giorgia Giovannini
PostDoc, Biomimetic Membranes and Textiles
Tel +41 58 765 78 03
giorgia.giovannini@empa.ch
Dr. Giorgia Giovannini PostDoc, Biomimetic Membranes and Textiles Tel +41 58 765 78 03 giorgia.giovannini@empa.ch