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Test-retest reliability of intra-epidermal electrically evoked potentials
The main tract for transmitting noxious stimuli is the spinothalamic tract, receiving its input from different types of small fibers in the skin i.e., mechanical- or heat-sensitive fibers. In spinal cord injury as in other pathologies involving neuropathic pain and sensation deficits, it is crucial to assess spinothalamic tract integrity with objective methods. This depends on a well-characterized stimulation modality, activating small fibers, and implies the recording of brain activity in response to this stimulation (electroencephalography; EEG). Intra-epidermal electrical stimulation (IES) using a concentric triple electrode is known for its clinical potential due to small fiber activation and is a good candidate for the activation of the spinothalamic tract. However, to implement IES as a diagnostic tool in the clinical routine, feasibility, and test-retest reliability need to be assessed compared to other stimulation modalities.
The study involves the recruitment and measurement of young healthy control subjects. You will acquire knowledge about neurophysiological techniques such as evoked potentials (EP) and electroencephalography (EEG). You will take part in data acquisition, analysis, and discussion of the findings.
The study involves the recruitment and measurement of young healthy control subjects. You will acquire knowledge about neurophysiological techniques such as evoked potentials (EP) and electroencephalography (EEG). You will take part in data acquisition, analysis, and discussion of the findings.
Six months project with the aim to test the feasibility, and test-retest reliability of intra-epidermal electrical stimulation (IES) to implement it as a diagnostic tool in the clinical routine.
Six months project with the aim to test the feasibility, and test-retest reliability of intra-epidermal electrical stimulation (IES) to implement it as a diagnostic tool in the clinical routine.
