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Characterization of the migratory process of high and low metastatic cells
Cell migration is fundamental in many processes such as embryonic development and wound healing, and plays an important role as well in pathologic situations, such as cancerous invasion. The study of the cell migration, and of the biomechanical properties of this process are therefore of great inter
Keywords: cancer, migration, invasion
In the present project we aim to characterize the migratory ability of high and low metastatic cell lines. Using cell transfection of fluorescent proteins to detect focal adhesions, live cell microscopy, and traction force methods adapted to our experimental needs, we will study the biomechanical properties of the migratory process in different cell types. The obtained time lapses will be analyzed to estimate migration speed and directionality, together with focal adhesion size and force generation in each cell type. The obtained data will be further used to find correlation dependencies between the different studied aspects.
In the present project we aim to characterize the migratory ability of high and low metastatic cell lines. Using cell transfection of fluorescent proteins to detect focal adhesions, live cell microscopy, and traction force methods adapted to our experimental needs, we will study the biomechanical properties of the migratory process in different cell types. The obtained time lapses will be analyzed to estimate migration speed and directionality, together with focal adhesion size and force generation in each cell type. The obtained data will be further used to find correlation dependencies between the different studied aspects.
The goal of this project is to describe the molecular and mechanical features of cell migration in normal and neoplastic cells.
The goal of this project is to describe the molecular and mechanical features of cell migration in normal and neoplastic cells.
Dr. Unai Silvan unai.silvan@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Jess Snedeker
Dr. Unai Silvan unai.silvan@hest.ethz.ch, Institute for Biomechanics, ETH Zürich, Professorship Jess Snedeker