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Physiological pressures and interdependencies in different body compartments
- Interdisciplinary research in biomedical engineering
- Analytical investigation of the interdependencies of the various body compartments
- Collaboration between the Institute of Physiology at the University of Zurich and the Product Development Group Zurich at ETH Zurich
Keywords: pathophysiology, intracranial pressure, new shunt systems, hydrocephalus
A disturbance of the balance between production, passage, and resorption of the cerebrospinal fluid into the bloodstream causes an expansion of the ventricles of the brain, described as hydrocephalus and can be treated with the placement of a shunt. Most shunt systems consist of a thin tube with a differential pressure valve and are placed from a lateral ventricle to the peritoneum (ventriculoperitoneal shunt). Due to posture changes, today's shunts suffer from drainage fluctuations and can overdrain. Our aim is to deeper understand the pathophysiologic processes of hydrocephalus also investigated in vitro.
A disturbance of the balance between production, passage, and resorption of the cerebrospinal fluid into the bloodstream causes an expansion of the ventricles of the brain, described as hydrocephalus and can be treated with the placement of a shunt. Most shunt systems consist of a thin tube with a differential pressure valve and are placed from a lateral ventricle to the peritoneum (ventriculoperitoneal shunt). Due to posture changes, today's shunts suffer from drainage fluctuations and can overdrain. Our aim is to deeper understand the pathophysiologic processes of hydrocephalus also investigated in vitro.
Based on recordings from implanted telemetric transmitters, pressure signals will be analyzed in various body compartments in particular intracranial pressure (ICP). We further want to derive an understanding of the physiologic pressure conditions in individual body compartments and their mutual influences. Gain an insight of the impact of the body posture and create a database on inter compartmental pressure dependencies. The data is acquired with the telemetry software Ponemah 6.41 (Data Sciences International St Paul, MN, USA) and is then imported and evaluated in MATLAB/Simulink (The MathWorks, Inc., Natick, MA, USA).
Based on recordings from implanted telemetric transmitters, pressure signals will be analyzed in various body compartments in particular intracranial pressure (ICP). We further want to derive an understanding of the physiologic pressure conditions in individual body compartments and their mutual influences. Gain an insight of the impact of the body posture and create a database on inter compartmental pressure dependencies. The data is acquired with the telemetry software Ponemah 6.41 (Data Sciences International St Paul, MN, USA) and is then imported and evaluated in MATLAB/Simulink (The MathWorks, Inc., Natick, MA, USA).
Not specified
Dr. Britta Bausch
University of Zurich Institute of Physiology
The Interface Group
Winterthurerstr. 190, Y23 J 78 8057 Zurich
britta.bausch@uzh.ch
Marianne Schmid Daners
ETH Zurich Product Development Group Zurich
Tannenstrasse 3
CLA G 21.1 8092 Zurich
marischm@ethz.ch
Dr. Britta Bausch University of Zurich Institute of Physiology The Interface Group Winterthurerstr. 190, Y23 J 78 8057 Zurich britta.bausch@uzh.ch
Marianne Schmid Daners ETH Zurich Product Development Group Zurich Tannenstrasse 3 CLA G 21.1 8092 Zurich marischm@ethz.ch